Results 41 to 50 of about 3,734,160 (288)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

How artificial intelligence can enable data classification for market sizing - Insights from applications in practice

open access: yesInternational Journal of Information Management Data Insights
Determining the size of the addressable market is a key aspect of market intelligence and requires identifying and delineating projected budget data from potential customers.
L. Stallings   +4 more
doaj   +1 more source

Exploring factors influencing pre-service teacher’s digital teaching competence and the mediating effects of data literacy: empirical evidence from China

open access: yesHumanities & Social Sciences Communications, 2023
The development of pre-service teachers’ digital teaching competence is crucial for effectively infusing technology into teaching. With the growing importance of data in education, it is imperative to explore the influencing factors of digital teaching ...
Juan Chu   +5 more
doaj   +1 more source

From the Editor [PDF]

open access: yes, 2015
[Excerpt] Digital. Digital. Digital. We have the pleasure of presenting another issue of Practical Technology for Archives that is full of great information on dealing with our digital ...
Miles, Randall
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

A Modular Heuristic-Based Solution for Large-Scale Outage Management in Nuclear Power Plants [PDF]

open access: yesEPJ Web of Conferences
The Resource Constrained Project Scheduling Problem (RCPSP) is a prominent combinatorial optimization problem in academia. It involves scheduling project activities while considering constraints arising from logical relationships between tasks, resource ...
Ninpan Khwansiri   +9 more
doaj   +1 more source

Idecomp: imbalance-aware decomposition for class-decomposed classification using conditional GANs

open access: yesDiscover Artificial Intelligence, 2023
Medical image classification tasks frequently encounter challenges associated with class imbalance, resulting in biased model training and suboptimal classification performance.
Patryk Buczek   +3 more
doaj   +1 more source

Digital Barriers: Making Technology Work for People [PDF]

open access: yes, 2010
This paper was originally given as an oral presentation at the ‘3rd International Conference for Universal Design’, International Association for Universal Design, Hamamatsu, Japan (2010) and subsequently published.
Bichard, Jo-Anne, Gheerawo, Rama
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Third Revolution Digital Technology in Disaster Early Warning [PDF]

open access: yes, 2015
Networking societies with electronic based technologies can change social morphology, where key social structures and activities are organized around electronically processed information networks.
Amaratunga, Dilanthi   +2 more
core  

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