Results 41 to 50 of about 1,680,483 (305)

An Improved Structural Analysis Method for Isolator with Quasi-Zero-Stiffness Characteristic

Shock and Vibration, 2021
A typical quasi-zero-stiffness (QZS) vibration isolator consisting of a vertical spring and two oblique springs has been widely researched on its static and dynamic characteristics.
Wei Zhang, Xiaoping Li, Jian Li, Xiqiu Li   +3 more
doaj   +1 more source

Digitalization Technologies for Industrial Sustainability

Procedia Manufacturing, 2019
Abstract Digital technologies are shown to perform a potential role in developing a resource efficient industrial base. The effective adoption of them can help to deliver reduced costs and improve the flexibility and sustainability of manufacturing systems.
Demartini M., Evans S., Tonelli F.
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Hybrid neural network for personnel recognition and tracking in remote bidding evaluation monitoring

Scientific Reports
Unauthorized access to the bidding evaluation office and the departure of experts can significantly compromise the quality of on-site assessment work and introduce substantial integrity risks.
Zhihao Zhou, Zhan Wang, Yuwei Meng, Rongdong Yu, Xingwei He, Ding Lu, Wei Wang   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Prediction uncertainty estimates elucidate the limitation of current NSCLC subtype classification in representing mutational heterogeneity

Scientific Reports
The heterogeneous pathogenesis and treatment response of non-small cell lung cancer (NSCLC) has led clinical treatment decisions to be guided by NSCLC subtypes, with lung adenocarcinoma and lung squamous cell carcinoma being the most common subtypes ...
Andrei Puiu, Carlos Gómez Tapia, Maximilian E. R. Weiss, Vivek Singh, Ali Kamen, Matthias Siebert   +5 more
doaj   +1 more source

Chest-scale self-compensated epidermal electronics for standard 6-precordial-lead ECG

npj Flexible Electronics, 2022
Six chest leads are the standardized clinical devices of diagnosing cardiac diseases. Emerging epidermal electronics technology shift the dangling wires and bulky devices to imperceptible wearing, achieving both comfortable experience and high-fidelity ...
Lang Yin, Youhua Wang, Jian Zhan, Yunzhao Bai, Chao Hou, Junfeng Wu, Rong Huang, Yuzhou Wang, YongAn Huang   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

How artificial intelligence can enable data classification for market sizing - Insights from applications in practice

International Journal of Information Management Data Insights
Determining the size of the addressable market is a key aspect of market intelligence and requires identifying and delineating projected budget data from potential customers.
L. Stallings, P. Bhat, J. Jacobs, K. Lynch, Q. Risch   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source