Results 61 to 70 of about 1,680,483 (305)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Multi-plane vision transformer for hemorrhage classification using axial and sagittal MRI data

Scientific Reports
Identifying brain hemorrhages from magnetic resonance imaging (MRI) is a critical task for healthcare professionals. The diverse nature of MRI acquisitions with varying contrasts and orientation introduces complexity in identifying hemorrhage using ...
Badhan Kumar Das, Gengyan Zhao, Boris Mailhe, Thomas J. Re, Dorin Comaniciu, Eli Gibson, Andreas Maier   +6 more
doaj   +1 more source

Making global sensitivity analysis feasible using neural network surrogates

Data-Centric Engineering
How can we make global sensitivity analysis accessible and viable for engineering practice? In this translation article, we present a methodology to enable sensitivity analysis for structural and geotechnical engineering for built environment design and ...
Gihan Weerasinghe, Ramaseshan Kannan, Samila Bandara   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Co-ordinate-based positional embedding that captures resolution to enhance transformer’s performance in medical image analysis

Scientific Reports
Vision transformers (ViTs) have revolutionized computer vision by employing self-attention instead of convolutional neural networks and demonstrated success due to their ability to capture global dependencies and remove spatial biases of locality.
Badhan Kumar Das, Gengyan Zhao, Saahil Islam, Thomas J. Re, Dorin Comaniciu, Eli Gibson, Andreas Maier   +6 more
doaj   +1 more source

“Just Asking Questions”: Doing Our Own Research on Conspiratorial Ideation by Generative AI Chatbots

Media and Communication
Interactive chat systems that build on artificial intelligence (AI) frameworks are increasingly ubiquitous and embedded into search engines, Web browsers, and operating systems, or as standalone websites and apps.
Katherine M. FitzGerald, Michelle Riedlinger, Axel Bruns, Stephen Harrington, Timothy Graham, Daniel Angus   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Digital ureteroscopes: technology update

Research and Reports in Urology, 2017
Chad M Gridley, Bodo E Knudsen Department of Urology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Abstract: The field of ureteroscopy has undergone a continual evolution since the first ureteroscopes were introduced.
Gridley CM, Knudsen BE
doaj  

ArtifactOps and ArtifactDL: a methodology and a language for conceptualizing and operationalising different types of pipelines

Journal of Cloud Computing: Advances, Systems and Applications
Machine learning is already integrated in diverse domains enhancing their performance and decision support. For laboratories, this approach is normally sufficient.
Raúl Miñón, Josu Diaz-de-Arcaya, Ana I. Torre-Bastida, Juan López-de-Armentia, Gorka Zarate, Lander Bonilla, Asier Garcia-Perez, Jon Aguirre-Usandizaga   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source