Results 111 to 120 of about 73,966 (319)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

Scientific Reports
Multiomics analyses have identified multiple potential biomarkers of the incidence and prevalence of complex diseases. However, it is not known which type of biomarker is optimal for clinical purposes.
Martin Smelik, Yelin Zhao, Xinxiu Li, Joseph Loscalzo, Oleg Sysoev, Firoj Mahmud, Dina Mansour Aly, Mikael Benson   +7 more
doaj   +1 more source

Foundational development, modeling and configuration of state stabilizing mechanism to maintain axial tension in ball screw feed drive systems

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This study presents a state stabilizing mechanism that can maintain consistent axial tension in the ball screw feed drive systems used within machine tools, even when the screw shaft is elongated due to thermal expansion.
Satoru ARAI, Yushi TAKENOUCHI, Shintaro HONDA, Shota TANI   +3 more
doaj   +1 more source

Digital twins for metrology; metrology for digital twins

Measurement Science and Technology
Abstract Digital twinning is a rapidly growing area of research. Digital twins combine models and data to provide up-to-date information about the state of a system. They support reliable decision-making in fields such as structural monitoring and advanced manufacturing.
Louise Wright, Stuart Davidson
openaire   +1 more source

Digital Twin for Neurology: An Introduction to a New Frontier in Healthcare

A digital twin (DT) is a virtual representation of a real thing that features two-way interactive links connecting the physical object and its digital twin.
Ashraf, Taniya, Chishti, Mohammad Ahsan, Raheem, Mohamed Mahees   +2 more
core   +1 more source

Digital twin of functional gating system in 3D printed molds for sand casting using a neural network [PDF]

, 2020
The filling stage is a critical phenomenon in sand casting for making reliable castings. Latest research has demonstrated that for most liquid engineering alloys, the critical meniscus velocity of the melt at the ingate is in the range of 0.4–0.6 m s−1 ...
EL MANSORI, Mohamed, KTARI, Ahmed
core  

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source