Results 111 to 120 of about 3,378,227 (313)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Digital Twin for 6G mobile networks [PDF]

openIl Digital Twin è uno strumento tecnologico innovativo che valuta e rende efficiente un sistema fisico. Il suo funzionamento si basa sul creare un duplicato virtuale connesso in tempo reale con il modello fisico e attraverso tecniche di intelligenza
MONTANA, ALFONSO
core  

Construction method of high-horsepower tractor digital twin [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background Agricultural machinery equipment is the core element of advanced agricultural productivity. The operation system of agricultural machinery equipment involves machine-human-environment-society interactions.
Zihan Yang, Yuefeng Du, Zhenghe Song, Du Chen, Zhongxiang Zhu, Yanan Zhang   +5 more
doaj   +1 more source

Digital Twin Channel for 6G: Concepts, Architectures and Potential Applications [PDF]

IEEE Communications Magazine
Digital twin channel (DTC) is the real-time mapping of radio channels and associated communication operations from the physical world to the digital world, which is expected to provide significant performance enhancements for the sixth-generation (6G ...
Heng Wang, Jianhua Zhang, Gaofeng Nie, Li Yu, Zhiqiang Yuan, Tongjie Li, Jialin Wang, Guangyi Liu   +7 more
semanticscholar   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Implementation of Digital Twin in warehouse [PDF]

openL'obiettivo della tesi è presentare come può essere implementato un sistema di Digital Twin all'interno del magazzino. Si osservano sia i vantaggi che questo sistema porta all'ambiente del magazzino, sia le criticità legate all'utilizzo del ...
BERTO, MATTEO
core  

Digital Twin—A Review of the Evolution from Concept to Technology and Its Analytical Perspectives on Applications in Various Fields

Applied Sciences
Digital Twin (DT) technology has experienced substantial advancements and extensive adoption across various industries, aiming to enhance operational efficiency and effectiveness.
Miruna-Elena Iliuţă, M. Moisescu, Eugen Pop, A. Ionita, S. Caramihai, Traian-Costin Mitulescu   +5 more
semanticscholar   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Digital twin applications in geo-engineering : a systematic literature review [PDF]

, 2023
LAUREA MAGISTRALEL'emergere dell'Industria 4.0 ha portato all'influenza onnipresente della rivoluzione informatica su vari aspetti dell'esistenza umana. All'interno di questo paradigma, il concetto di gemello digitale ha raccolto una notevole attenzione ...
Yang, Chunjun
core