Results 41 to 50 of about 37,425,541 (269)

Building Digital Twin Data Model Based on Public Data

Buildings
This study aims to propose a method for constructing basic digital twin data in South Korea by adhering to international standards and by utilizing publicly available data.
Dawoon Jeong, Changyun Lee, Youngmin Choi, Taeyun Jeong   +3 more
doaj   +1 more source

A review of the technology standards for enabling digital twin [version 1; peer review: 2 approved]

Digital Twin, 2022
In the process of developing digital twin enabling applications, a lack of reference to standards related to digital twin terms, architecture and models leads to differences between users' understanding of digital twin, and it is difficult to realize the
Kai Wang, Yizheng Li, Yamin Wang, Shanpeng Xiao, Xiaohui Fan, Lin Hu   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer

Scientific Reports
Pancreatic cysts, particularly intraductal papillary mucinous neoplasms (IPMNs), pose a potential risk for progressing to pancreatic cancer (PC). This study investigates the genetic architecture of benign pancreatic cysts and its potential connection to ...
A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li   +7 more
doaj   +1 more source

Digital twin modeling method for environmental governance of abandoned landfills based on multi-agent systems [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]

Digital Twin
Background It is currently observed that some landfills are experiencing severe overloading, with some having ceased operations. However, they continue to threaten the environment and public health.
Zehua Zhang, Zhansheng Liu, Linlin Zhao, Qingwen Zhang   +3 more
doaj   +1 more source

Intelligent digital twins and the development and management of complex systems [version 1; peer review: 4 approved]

Digital Twin, 2022
The interest in defining and implementing Digital Twins (DT) is at the forefront of today’s product organizations. The evolution of increasingly complex systems requires that their information be organized and managed via digital twins.  In addition, the
Michael Grieves
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Una procedura per l’Historic Digital Twin (HDT) dei ponti ad arco in muratura/ A procedure for Heritage Digital Twin (HDT) of masonry arch bridges.

, 2021
The research presented here aims to define an operational procedure for analysing historic masonry arch bridges and developing digital replicas. Through the integration of different disciplines and tools, the digital model of the historic bridge of Fossa
Savini F., Marra A., Trizio I., Ruggieri A., Fabbrocino G.   +4 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Two-Dimensional Materials, the Ultimate Solution for Future Electronics and Very-Large-Scale Integrated Circuits

Nano-Micro Letters
Highlights With the incessant down-scaling of electronics, traditional semiconductors like Si are encountered with insurmountable hurdles to maintain performance increase without bringing about additional issues of power consumption escalating, in this ...
Laixiang Qin, Li Wang
doaj   +1 more source