Results 51 to 60 of about 37,425,541 (269)

Digital Twins along the product lifecycle: A systematic literature review of applications in manufacturing [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background The evolution of product expectations in the era of mass personalization implies an improvement and a better control of individualized creation and production processes throughout the product lifecycle.
Frédérique Mayer, Guillaume Pronost, Laurent Dupont, Mauricio Camargo   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modeling and Simulating Cities with Digital Twins

, 2022
The digital twin concept has virtually exploded in recent years, but within the built environment the traditional term has long been ‘3D city model’. However, the digital twin concept is increasingly gaining acceptance as a useful concept that extends ...
Logg, Anders,, Naserentin, Vasilis,
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Digital twin method and application practice of spacecraft system driven by mechanism data [version 2; peer review: 1 approved, 2 approved with reservations]

Digital Twin
Spacecrafts are large-scale systems characterized by various on-orbit configurations, multi-disciplinary coupling, and complex mission modes. Research and exploration on the data-driven spacecraft digital twins development methods must be carried out to ...
Zhou Fanli, Huang Lei, Shang Shuai, Wang Wei, Zhou Haocheng   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Towards a shape-performance integrated digital twin for lumbar spine analysis [version 2; peer review: 2 approved, 1 not approved]

Digital Twin
Background With significant advancement and demand for digital transformation, the digital twin has been gaining increasing attention as it is capable of establishing real-time mapping between physical space and virtual space.
Wei Sun, Xueguan Song, Xiwang He, Xiaonan Lai, Yiming Qiu, Liming Shu, Zhonghai Li   +6 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Construction method of high-horsepower tractor digital twin [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background Agricultural machinery equipment is the core element of advanced agricultural productivity. The operation system of agricultural machinery equipment involves machine-human-environment-society interactions.
Zihan Yang, Yuefeng Du, Zhenghe Song, Du Chen, Zhongxiang Zhu, Yanan Zhang   +5 more
doaj   +1 more source