Results 51 to 60 of about 3,509,576 (320)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Digital twin data: methods and key technologies [version 1; peer review: 1 approved, 3 approved with reservations]

Digital Twin, 2021
As a promising technology to converge the traditional industry with the digital economy, digital twin (DT) is being investigated by researchers and practitioners across many different fields. The importance of data to DT cannot be overstated.
Ang Liu, Meng Zhang, Lihui Wang, Fei Tao, Biqing Huang, A. Y. C. Nee, Nabil Anwer   +6 more
doaj   +1 more source

Mapping an ancient historian in a digital age: the Herodotus Encoded Space-Text-Image Archive (HESTIA) [PDF]

, 2010
HESTIA (the Herodotus Encoded Space-Text-Imaging Archive) employs the latest digital technology to develop an innovative methodology to the study of spatial data in Herodotus' Histories.
Barker, Elton, Bouzarovski, Stefan, Isaksen, Leif, Pelling, Chris   +3 more
core  

Standardization Framework for Sustainability from Circular Economy 4.0 [PDF]

, 2019
The circular economy (CE) is widely known as a way to implement and achieve sustainability, mainly due to its contribution towards the separation of biological and technical nutrients under cyclic industrial metabolism.
Aguayo-González, Francisco, Aguayo-González, Francisco (Coordinador), Córdoba-Roldán, Antonio, Martín-Gómez, Alejandro Manuel, Ávila-Gutiérrez, María Jesús   +4 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Building Digital Twin Data Model Based on Public Data

Buildings
This study aims to propose a method for constructing basic digital twin data in South Korea by adhering to international standards and by utilizing publicly available data.
Dawoon Jeong, Changyun Lee, Youngmin Choi, Taeyun Jeong   +3 more
doaj   +1 more source

Digital twin data: methods and key technologies [version 2; peer review: 4 approved]

Digital Twin, 2022
As a promising technology to converge the traditional industry with the digital economy, digital twin (DT) is being investigated by researchers and practitioners across many different fields. The importance of data to DT cannot be overstated.
Ang Liu, Meng Zhang, Lihui Wang, Fei Tao, Biqing Huang, A. Y. C. Nee, Nabil Anwer   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Digital twin modeling method for environmental governance of abandoned landfills based on multi-agent systems [version 1; peer review: 2 approved, 1 approved with reservations, 1 not approved]

Digital Twin
Background It is currently observed that some landfills are experiencing severe overloading, with some having ceased operations. However, they continue to threaten the environment and public health.
Zehua Zhang, Zhansheng Liu, Linlin Zhao, Qingwen Zhang   +3 more
doaj   +1 more source

Web-based digital twin online laboratories: Methodologies and implementation [version 3; peer review: 2 approved, 1 approved with reservations]

Digital Twin, 2023
Background: Online laboratories that provide online experimentation are crucial for education and research in all fields of engineering. As a transformative technology, the digital twin can be potentially applied into online laboratories to enable ...
Zhongcheng Lei, Wenshan Hu, Hong Zhou, Guo-Ping Liu   +3 more
doaj   +1 more source