Results 71 to 80 of about 73,966 (319)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Digital twin method and application practice of spacecraft system driven by mechanism data [version 2; peer review: 1 approved, 2 approved with reservations]

Digital Twin
Spacecrafts are large-scale systems characterized by various on-orbit configurations, multi-disciplinary coupling, and complex mission modes. Research and exploration on the data-driven spacecraft digital twins development methods must be carried out to ...
Zhou Fanli, Huang Lei, Shang Shuai, Wang Wei, Zhou Haocheng   +4 more
doaj   +1 more source

Video for "Outlining of the Open Digital Twin Platform"

, 2023
Complex simulations and machine-learning models increase in application in research, industry, and governance. However, applying these systems with reasonable accuracy and efficiency requires large-scale efforts of data collection, data transformation ...
Xin, Yanan, Riba Grognuz, Oksana, Grübel, Jascha, Ivanovic, Stefan, Franken, Robin M., Raubal, Martin, Axhausen, Kay W., Zuo, Chenyu, Ossey, Sabrina, Vivar Rios, Carlos, Balac, Milos   +10 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Towards a shape-performance integrated digital twin for lumbar spine analysis [version 2; peer review: 2 approved, 1 not approved]

Digital Twin
Background With significant advancement and demand for digital transformation, the digital twin has been gaining increasing attention as it is capable of establishing real-time mapping between physical space and virtual space.
Wei Sun, Xueguan Song, Xiwang He, Xiaonan Lai, Yiming Qiu, Liming Shu, Zhonghai Li   +6 more
doaj   +1 more source

Developing a calibrated physics-based digital twin for construction vehicles

This paper presents the development and calibration of a digital twin for a wheel loader that integrates a physical machine with a high-fidelity virtual model.
Lindmark, Daniel, Ravani, Bahram, Karanfil, Deniz, Servin, Martin, Torick, David   +4 more
core   +1 more source

Enhancing metal-forming predictions with VR-infused digital twin models [PDF]

This article presents a two-step method to enhance metal-forming predictions by integrating Virtual Reality (VR) into Digital Twin models, focusing on single-blow cold copper upsetting operations. The process begins with developing a real-time predictive
DURAND, Camille, Durand, Camille, Jeanne Margot, BIGOT, Regis, LOCARD, Yoan, URIBE, David, BAUDOUIN, Cyrille   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A Study on Guidelines for Constructing Building Digital Twin Data

Buildings
In South Korea, to systematically share and operate data related to the national level of the digital twin, a reference model standard for the National Digital Twin (NDT) concept was established in 2021.
Dawoon Jeong, Taeyun Jeong, Changyun Lee, Youngmin Choi, Dohun Lee   +4 more
doaj   +1 more source