Results 71 to 80 of about 3,509,576 (320)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Two-Dimensional Materials, the Ultimate Solution for Future Electronics and Very-Large-Scale Integrated Circuits

Nano-Micro Letters
Highlights With the incessant down-scaling of electronics, traditional semiconductors like Si are encountered with insurmountable hurdles to maintain performance increase without bringing about additional issues of power consumption escalating, in this ...
Laixiang Qin, Li Wang
doaj   +1 more source

Acute fetal anemia diagnosed by middle cerebral artery Doppler velocimetry in stage v twin-twin transfusion syndrome. [PDF]

, 2011
In stage V twin-twin transfusion syndrome (TTTS), up to 50% of surviving twins die or experience permanent disabilities, likely due to acute intertwin hemorrhage resulting in sudden severe anemia of the survivor.
Friedrich, Esther, Porto, Manuel, Salcedo, Jennifer, Wing, Deborah A   +3 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Artificial intelligence in the digital twins: State of the art, challenges, and future research topics [version 2; peer review: 2 approved]

Digital Twin, 2022
Advanced computer technologies such as big data, Artificial Intelligence (AI), cloud computing, digital twins, and edge computing have been applied in various fields as digitalization has progressed.
Zhihan Lv, Shuxuan Xie
doaj   +1 more source

Human-Machine Interface for Remote Training of Robot Tasks

, 2018
Regardless of their industrial or research application, the streamlining of robot operations is limited by the proximity of experienced users to the actual hardware.
Boukas, Evangelos, Buzatoiu, Roxana, Nalpantidis, Lazaros, Polydoros, Athanasios, Spranger, Jordi   +4 more
core   +1 more source

Towards design of prognostics and health management solutions for maritime assets [PDF]

, 2017
With increase in competition between OEMs of maritime assets and operators alike, the need to maximize the productivity of an equipment and increase operational efficiency and reliability is increasingly stringent and challenging. Also, with the adoption
Niculita, Octavian, Nwora, Obinna, Skaf, Zakwan   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Digital Twin

, 2023
Denne masteroppgaven har som mål å bidra til å utvikle en Digital Tvilling som i samarbeid med industrielle samarbeidspartnere er på vei. Oppgaven produserer pålitelige eksperimentelle caser som lager et solid fundament for framtidig bruk i en Digital Tvilling.
Ranjan Ganguli, Sondipon Adhikari, Souvik Chakraborty, Mrittika Ganguli   +3 more
openaire   +3 more sources

Digital twin method and application practice of spacecraft system driven by mechanism data [version 2; peer review: 1 approved, 2 approved with reservations]

Digital Twin
Spacecrafts are large-scale systems characterized by various on-orbit configurations, multi-disciplinary coupling, and complex mission modes. Research and exploration on the data-driven spacecraft digital twins development methods must be carried out to ...
Zhou Fanli, Huang Lei, Shang Shuai, Wang Wei, Zhou Haocheng   +4 more
doaj   +1 more source