Results 61 to 70 of about 73,966 (319)

Intelligent digital twins and the development and management of complex systems [version 1; peer review: 4 approved]

Digital Twin, 2022
The interest in defining and implementing Digital Twins (DT) is at the forefront of today’s product organizations. The evolution of increasingly complex systems requires that their information be organized and managed via digital twins.  In addition, the
Michael Grieves
doaj   +1 more source

Trust model for digital twin based recommendation system

, 2022
The digital twin has been gaining significant attention from the academia and industry sectors in the last few years. The digital twin concept enables monitoring, diagnosis, optimisation, and decision support tasks to improve industrial systems operation.
Moreira, António Paulo G. M., Leitão, Paulo, Pires, Flávia   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer

Scientific Reports
Pancreatic cysts, particularly intraductal papillary mucinous neoplasms (IPMNs), pose a potential risk for progressing to pancreatic cancer (PC). This study investigates the genetic architecture of benign pancreatic cysts and its potential connection to ...
A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li   +7 more
doaj   +1 more source

Digital Twins along the product lifecycle: A systematic literature review of applications in manufacturing [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background The evolution of product expectations in the era of mass personalization implies an improvement and a better control of individualized creation and production processes throughout the product lifecycle.
Frédérique Mayer, Guillaume Pronost, Laurent Dupont, Mauricio Camargo   +3 more
doaj   +1 more source

Urban digital twins: Digital twins for participatory steering

New Media & Society
Originating in the field of manufacturing, the Digital Twin (DT) concept is now being applied across a range of application domains, from personal healthcare to whole Earth observation. Despite enthusiasm for DTs, uncertainties have arisen concerning their lack of definition and technical specificity.
Oliver Dawkins, Rob Kitchin
openaire   +3 more sources

Creating a digital twin in meteorological forecasting for a smart city on a mobile platform

, 2023
The article discusses the application of the concept of a digital twin in the field of weather forecasting to create a smart city. A digital twin is a virtual replica of a real object or process that reflects its state in real time.
Doroshenko, A.Y., Haidukevych, V.O.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Current Trends in Digital Twin Development, Maintenance, and Operation: An Interview Study [PDF]

This talk is based on our paper entitled “Current Trends in Digital Twin development, maintenance, and operation: An interview study” published in the Journal of Software and Systems Modeling in April ...
Haverkort, Boudewijn, Cleophas, Loek, Muctadir, Hossain Muhammad; id_orcid, Gunasekaran, Raghavendran, van den Brand, Mark; id_orcid, Cleophas, Loek; id_orcid, Muctadir, Hossain Muhammad, Negrin, David M., Haverkort, Boudewijn R., van den Brand, Mark, Negrin, David A. Manrique; id_orcid   +10 more
core   +1 more source

A Digital Twin Framework for Precision Neuromusculoskeletal Health Care: Extension Upon Industrial Standards

, 2023
There is a powerful global trend toward deeper integration of digital twins into modern life driven by Industry 4.0 and 5.0. Defense, agriculture, engineering, manufacturing, and urban planning sectors have thoroughly incorporated digital twins to great ...
Claudio Pizzolato, Saxby, David J, Laura E. Diamond, Diamond, Laura E, Pizzolato, Claudio, David J. Saxby   +5 more
core   +1 more source