Results 101 to 110 of about 102,393 (385)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Development of STEM skills and competencies through object-based STEM learning
Smart Cities and Regional Development JournalDeveloping STEM competencies is a key topic in the education system in the EU and beyond. Many studies have proven the importance of Competence-Based Education (CBE) and its methods applied in the classroom.
Milena KRUMOVA
doaj +1 more source
CTE Workshop Proceedings, 2017 Research goals: analyze of the scientists experience of Estonia for the design of digital learning ecosystem for massive online courses and distinguish the main stages and tools for the design of massive online courses.
N. V. Soroko
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Collaboration Between Industrial, Collaborative, Humanoid Robots and Humans.
Journal of Machine EngineeringOne of the key aspects of Industrial Revolution 5.0 is the reintegration of humans into the industrial environment. This process enhances the interaction between various robots and humans in industry.
Vjatsheslav Kekshin +4 more
doaj +1 more source
Forming a learning environment using social cloud services
CTE Workshop Proceedings, 2013 Current educational processes are unthinkable without the use of information technology. This demand for them forces educational institutions to constantly increase the financial cost of purchasing and maintaining hardware and software.
V. H. Hrytsenko
doaj +1 more source
MAP Position Paper (Centro, Portugal) - Digitalisation in rural areas
, 2022 Marta Mendes, Pedro Santos
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Using learning management system for future skilled workers training in vocational schools
CTE Workshop Proceedings, 2014 The aim of this study is to determine the organizational and pedagogical conditions of implementation of information and communication technologies in vocational school distance education.
V. V. Gluschenko
doaj +1 more source
On the inclusion of sustainability and digitalisation in quality management – an overview from past to present [PDF]
, 2020 Daniel Carnerud +3 more
openalex +1 more source