Results 51 to 60 of about 5,811 (212)

Implementation and Rollout of a Trusted AI-Based Approach to Identify Financial Risks in Transportation Infrastructure Construction Projects

Applied System Innovation
Using big data for risk analysis of construction projects is a largely unexplored area. In this traditional industry, risk identification is often based either on so-called domain expert knowledge, in other words on experience, or on different ...
Michael Grims, Daniel Karas, Marina Ivanova, Gerhard Höfinger, Sebastian Bruchhaus, Marco X. Bornschlegl, Matthias L. Hemmje   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Count your bits: fingerprint benchmarking to assess broad chemical space representation

Journal of Cheminformatics
Quantifying molecular similarity is a cornerstone of cheminformatics, underpinning applications from virtual screening and nearest-neighbor search to chemical space visualization and the evaluation of machine-learning predictions. Yet, despite widespread
Florian Huber, Julian Pollmann
doaj   +1 more source

Encyclopedic web resources and generative artificial intelligence: a methodological dimension

CTE Workshop Proceedings
This article addresses a critical gap in the methodological foundations for designing, operating, and developing encyclopedic web resources in the context of generative artificial intelligence (GenAI) integration.
Valerii Yu. Bykov, Olha P. Pinchuk
doaj   +1 more source

Prospects for using cloud technologies in school physics experiments

CTE Workshop Proceedings, 2013
In some teaching physics experiments (e.g., fast-flow, slow-flow), there are characteristic problems associated with trying to capture a number of quantities. One way to solve these problems is the use of computer technology.
O. V. Merzlykin
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

FOREIGN AND UKRAINIAN EXPERIENCE IN THE FORMATION AND USE OF FAIR DATA IN EDUCATIONAL RESEARCH

Неперервна професійна освіта: теорія та практика
This article highlights the issue of responsible experimental data management within the context of scientific digitalisation and the transition towards the Open Science paradigm.
Vasyl Oleksiuk , Oleh Spirin, Kateryna Osadcha , Mykola Shynenko   +3 more
doaj   +1 more source