Results 51 to 60 of about 32,919 (306)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

DIGITALISATION AND EUROPEAN WELFARE STATES. BLUEPRINT SERIES 30. Bruegel [PDF]

, 2019
Rapid technological progress and innovation can destroy jobs. This is not a new concern. Throughout history, with a great speeding-up during the Industrial Revolution, automation of production processes has led to efficiency gains and to the ...
Marcus, J. Scott, Moës, Nicolas, Petropoulos, Georgios, Bergamini, Enrico   +3 more
core  

Development of a computer-based learning environment in the conditions of multicultural education in the European Union

Освітній вимір, 2020
In the article, based on the results of the analysis of scientific and pedagogical works of domestic and foreign scientists, the concept of multicultural competence of the student and the concept of computer-oriented learning environment in the ...
Iryna Ivaniuk
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Path2dea survey on digitalisation

, 2023
Path2dea (PAving THe way towards Digitalisation Enabeling Agroecology) first results of a survey on digitalisation presented within the workshop on Digitalisation for sustainable farming organized by the European Policy ...
Herforth-Rahmé, Joelle
core  

European strategy for determining the level of competence in the field of digital technologies: a framework for digital competence for citizens

Освітній вимір, 2020
The Digital Competence Framework for Citizens (DigComp 2.0: Digital Competence Framework for Citizens), presented by the European Commission in 2016 and modernized in 2017 (DigComp 2.1) is supplemented with examples of application in different European ...
Oksana Ovcharuk
doaj   +1 more source

The experience of designing a single information and educational environment of the university "NMU Digital"

Educational Technology Quarterly, 2022
The publication considers theoretical and practical approaches to the design and creation of a single information and educational environment of the Bogomolets National Medical University. The main factors that were taken into account in the development
Yuriy Kuchyn, Oleksandr Naumenko, Oleg Vlasenko, Svitlana Lytvynova, Oleksandr Burov, Inna Kucherenko, Pavlo Mykytenko   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Is Knowledge Ambidexterity the Answer to Economic Sustainability for SMEs? Lessons Learned from Digitalisation Efforts During the COVID-19 Pandemic

, 2023
Economic sustainability has always been a major challenge for small and medium enterprises (SMEs), which intensified during the COVID-19 pandemic. We propose that the implementation of knowledge ambidexterity (KA) can be a solution for the economic ...
Saratchandra, Minu, Shrestha, Anup
core   +1 more source