Results 61 to 70 of about 32,919 (306)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Start-ups and digitalisation for circular economy in India and Europe
, 2023 The chapter showcases some key circular economy innovations in India and the European Union. The chapter is divided into two parts. The first part focuses on three illustrative case studies of circular economy start-ups in India located across different ...
Banerjee, Abhijit +2 more
core +1 more source
Encyclopedic web resources and generative artificial intelligence: a methodological dimension
CTE Workshop ProceedingsThis article addresses a critical gap in the methodological foundations for designing, operating, and developing encyclopedic web resources in the context of generative artificial intelligence (GenAI) integration.
Valerii Yu. Bykov, Olha P. Pinchuk
doaj +1 more source
Digitalisation and the UN Sustainable development Goals: What role for design
Interaction Design and Architecture(s), 2018 This paper investigates the relation between digitalisation and the Sustainable Development Goals (SDGs). Digitalisation is often presented as a transformative power, changing the way we live and work.
Maja van der Velden
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Effects of a Multifunctional Cover Crop (LivinGro®) on Soil Quality Indicators in Zaragoza, Spain
LandSoil degradation is a significant threat to agricultural systems and contemporary societies worldwide, especially in the context of climate change.
Javier González-Pérez +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source