Results 61 to 70 of about 9,708 (241)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Machine learning integration in cryptocurrency trading and its fintech implications

Discover Artificial Intelligence
This review synthesises research on fintech implications of integrating machine learning algorithms into cryptocurrency trading strategies to address the fragmented understanding of their impact on trading efficacy, risk management, and financial ...
Péter Lengyel, János Pancsira, István Füzesi   +2 more
doaj   +1 more source

Development of STEM skills and competencies through object-based STEM learning

Smart Cities and Regional Development Journal
Developing STEM competencies is a key topic in the education system in the EU and beyond. Many studies have proven the importance of Competence-Based Education (CBE) and its methods applied in the classroom.
Milena KRUMOVA
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Collaboration Between Industrial, Collaborative, Humanoid Robots and Humans.

Journal of Machine Engineering
One of the key aspects of Industrial Revolution 5.0 is the reintegration of humans into the industrial environment. This process enhances the interaction between various robots and humans in industry.
Vjatsheslav Kekshin, Sergei Ponomar, Martinš Sarkans, Vladimir Kuts, Sergei Pavlov   +4 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

The results of implementation methods of using cloud technologies as tools of formation high school students’ research competencies in profile physics learning

CTE Workshop Proceedings, 2015
The purpose of this study is experimental verification of the methods of using cloud technologies as tools of high school students’ research competencies forming in profile physics learning.
O. V. Merzlykin
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

The cloud-based learning environment of educational institutions: the current developments

CTE Workshop Proceedings, 2014
The purpose of the article is to describe the state of the art of cloud-based learning environment formation and current developments of its design, the main task – analyze of cloud-based learning tools and services use at the educational institutions ...
Mariya Pavlivna Shyshkina
doaj   +1 more source