Results 91 to 100 of about 262,727 (287)

Digitalization and Innovation [PDF]

Developments in digital technology offer new opportunities to design new products and services. However, creating such digitalized products and services often creates new problems and challenges to firms that are trying to innovate.
Yoo, Youngjin
core  

Innovating the delivery of individual services within Flemish cities: inventory of ICT-driven heterogeneity [PDF]

, 2012
Flemish cities are setting up large scale reform trajectories to make their transactional service delivery more customer orientated, customer friendly and integrated.
De Rynck, Filip, Vander Elst, Simon
core  

Digital Modernity

Foundations and Trends® in Web Science, 2022
"Modernity” is a social, cultural or historical descriptor for a certain type of society or set of social arrangements. This monograph reviews narratives of digital modernity, without endorsing them; as narratives, they selectively discuss aspects of our sociotechnical context, descriptively, teleologically or normatively.
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Governance of Digitalization in Europe A contribution to the Exploration Shaping Digital Policy - Towards a Fair Digital Society? BertelsmannStiftung Study [PDF]

, 2020
Digital policy is a unique policy area. As a cross-cutting policy issue, it has an impact not only on individual areas of regulation but on almost all other policy areas as well.
Ferro, Carolina, Wagner, Ben
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Spatial variations of runoff thresholds associated with changes in land use over the period 1990-2018 in the Mediterranean side of Andalusia

Investigaciones Geográficas
The runoff threshold is the amount of precipitation that exceeds the infiltration capacity of the soil and from which water begins to flow over the land surface.
Héctor Álvarez-García, José Antonio Sillero-Medina, María Eugenia Pérez-González, José Damián Ruiz-Sinoga   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Pregnancy‐Related Risk Factors Are Associated With a Significant Burden of Treated Hypertension Within 10 Years of Delivery: Findings From a Population‐Based Norwegian Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe association between pregnancy complications and women's later cardiovascular disease has, primarily, been evaluated in studies lacking information on important covariates. This report evaluates the prospective associations between pregnancy‐
Grace M. Egeland, Svetlana Skurtveit, Anne Cathrine Staff, Geir Egil Eide, Anne‐Kjersti Daltveit, Kari Klungsøyr, Lill Trogstad, Per M. Magnus, Anne Lise Brantsæter, Margaretha Haugen   +9 more
doaj   +1 more source