Results 71 to 80 of about 118,501 (319)

Digidem Digest - Issue 24 (March 2020)

open access: yes, 2020
The Digidem Digest literature radar was a monthly curated overview of the latest publications with relevance to the research group "Democracy and Digitalization" at the Weizenbaum Institute.
Thiel, Thorsten
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Grounding Digitalization

open access: yes
Digitalization is usually perceived as an invisible process and its cultural embeddedness as well as its material, spatial, and environmental grounding are often neglected. However, digital technologies and transformations are shaped not only by cultural

core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Trajectory Tracking Nonlinear Hybrid Control of Automated Guided Vehicles

open access: yesComplexity
Automated guided vehicles (AGVs), so necessary in industrial environments, require precise control of trajectory tracking to make accurate stops at logistics stations, such as loading stations, or to pick up or drop off trolleys, pallets, or racks.
Antonio Sánchez-Rodríguez   +3 more
doaj   +1 more source

PURITY: An Industry-Standard-Based Security Framework for IT-OT Convergence

open access: yesIEEE Access
The convergence of Information Technology (IT) and Operational Technology (OT) introduces complex cybersecurity challenges, particularly for industrial control systems.
Franz-Karl Schachinger   +2 more
doaj   +1 more source

Digidem Digest - Issue 36 (May 2021)

open access: yes, 2021
The Digidem Digest literature radar was a monthly curated overview of the latest publications with relevance to the research group "Democracy and Digitalization" at the Weizenbaum Institute.
Thiel, Thorsten
core   +1 more source

Digital (In)Equality, Digital Inclusion, Digital Humanism

open access: yes12th ACM Conference on Web Science Companion, 2020
From its inception, the World Wide Web has been intended to be a force for social good. But there are many barriers and obstacles, a situation commonly characterized as the Digital Divide. Several billion people especially in the Global South do not have access to Internet/Web for reasons of lacking (affordable) infrastructure, poverty, low literacy ...
Anna Bon, Hans Akkermans
openaire   +2 more sources

Digital humanities and digital social reading [PDF]

open access: yesDigital Scholarship in the Humanities, 2019
Abstract Prominent among the social developments that the web 2.0 has facilitated is digital social reading (DSR): on many platforms there are functionalities for creating book reviews, ‘inline’ commenting on book texts, online story writing (often in the form of fanfiction), informal book discussions, book vlogs, and more.
Simone Rebora   +10 more
openaire   +5 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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