Results 51 to 60 of about 271,772 (303)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Design of an Efficient Interconnection Network of Temperature Sensors [PDF]
, 2010 Temperature has become a first class design constraint because high temperatures adversely affect circuit reliability, static power and degrade the performance. In this scenario, thermal characterization of ICs and on-chip temperature monitoring represent
Gomez Osuna, Carlos +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
IEEE Access, 2022 The distribution of information through web protocols is today based on the client-server model. Recently, decentralized protocols with greater availability appear as well as blockchain-based attestation methods, allowing for proving the existence of ...
Felix Harer, Hans-Georg Fill
doaj +1 more source
Efectos de la ruptura digital en prácticas de medios populares en Brasil [PDF]
, 2018 This article discusses the digital disruption in popular media practices in Brazil. It is based on interviews conducted from 2014 to 2016 with 55 communicators attached to 20 social movements and community associations all over the country.
Suzina, Ana Cristina
core +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Toward deep assessments: On the possibility of decolonial digital technologies
TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und PraxisConsidering the coloniality of current digital tools and their increasingly massive global social and ecological impacts, we explore the question of what socio-cultural assemblages can contribute to deep civilizational transformations.
Dorian Cavé, Rainer Rehak
doaj +1 more source
Internet of Things and Their Coming Perspectives: A Real Options Approach [PDF]
, 2019 Internet of things is developing at a dizzying rate, and companies are forced to implement it in order to maintain their operational efficiency. The high flexibility inherent to these technologies makes it necessary to apply an appropriate measure, which
Cruz Rambaud, Salvador +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MachinesThis work proposes a general methodology for the design and experimental validation of dual-arm robotic platforms intended for intelligent manipulation tasks in real-world environments.
Mario Peñacoba-Yagüe +1 more
doaj +1 more source