Results 61 to 70 of about 114,533 (280)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
How do we teach Filmmaking – given the rapid changes in digital technology? [PDF]
, 2012 “Gutenberg's concept of movable type transcended the medium used for the printing itself. Digital, perhaps, may prove to be paper to celluloid’s parchment.” [Murch, 1999] With the recent cessation of production of 35mm cinema cameras [Kaufman, 2011] and ...
Anderson, L
core
Privileged Mexican migrants in Europe: Distinctions and cosmopolitanism on social networking sites [PDF]
, 2014 This article examines the ways in which classed distinctions are related to the construction of increasingly cosmopolitan identities on Social Networking Sites (SNSs) amongst Mexican migrants from relatively privileged backgrounds living in Europe.
Bailey, OG, Nessi, L
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Digitalization of Legal Education
Uzbek Journal of Law and Digital Policy, 2023 The digital revolution has transformed many aspects of our lives, including legal education. The emergence of new technologies has given rise to new opportunities for legal education, such as online courses and digital resources. However, the digitalization of legal education has also presented a range of challenges, from ensuring quality control to ...
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Inclusive Growth – an Agenda for Germany Five action areas for a new growth strategy. Bertelsmann Stiftung Inclusive Growth for Germany|20 [PDF]
, 2017 Germany is entering a new legislative period with a strong economic position. Across the board, current figures and forecasts for the near future are encouraging.
Barišić , Manuela +4 more
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European emergency coordination. ZEI Discussion Paper C259 2020 [PDF]
, 2020 The European elections in 2019 sent two messages. Firstly, Europe is stronger than what its opponents thought it would be. Despite major challenges like Brexit and migration, the results of the election demonstrated strong European cohesion.
Stylianides, Christos
core
The DiSCmap project : overview and first results [PDF]
, 2009 Traditionally, digitisation of cultural and scientific heritage material for use by the scholarly community has been led by supply rather than demand.
Birrell, Duncan +5 more
core +1 more source