Results 71 to 80 of about 114,533 (280)

CURRENT TRENDS OF DIGITAL TRANSFORMATION OF EDUCATION

Vestnik Majkopskogo Gosudarstvennogo Tehnologiceskogo Universiteta, 2022
Digital resources today are reliably included in the practice of managerial and educational activities of the education system at all levels. The digital transformation of education is considered among the strategic directions for the development of the institution of education, which involves the development of priority ways to expand the scale and ...
Inna Nikolaevna Guchetl, Tatyana Vyacheslavovna Manchenko   +1 more
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Digitalization of Education

International Journal of Academic Research in Progressive Education and Development, 2023
Aminamul Saidah Mad Nordin, Bity Salwana Alias   +1 more
openaire   +2 more sources

Selling out Education in the Name of Digitalization: A Critical Analysis of Swedish Policy

Nordic Journal of Studies in Educational Policy, 2021
Sweden aspires to become ‘the best in the world at utilizing the opportunities of digitalization’ and is internationally recognized for its digital performance.
Marita Ljungqvist, Anders Sonesson
doaj   +1 more source

STRATEGI PEMERINTAH KOTA MALANG DALAM PENGEMBANGAN DIGITAL USAHA MIKRO DI KOTA MALANG [PDF]

, 2023
Digitalization is something that cannot be avoided in this world. Technological advancements have made everything shift towards digitalization. From business models to education, even governments have to adapt to technological developments.
Rahardi, Fauzi Hafizh
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Digital Maturity in Education

Nordic Journal of Digital Literacy
As educational institutions navigate the complexities of digital transformation, understanding the factors that drive successful technology integration is essential. The implementation of digital tablets in schools is becoming increasingly common. Through the application of the digital maturity framework, a Structural Equation Modeling (SEM) analysis ...
Nielsen, Bettina, Egeberg, Gunstein Christoffer, Svihus, Cathrine   +2 more
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Digitalization and Inclusive Education: Common Ground

Высшее образование в России, 2020
The article addresses the issues related to digitalization in education and in this context – using of its achievements in the inclusive education.The authors analyze the implementation of digital technologies in the educational system, the benefits and ...
D. Z. Akhmetova, T. S. Artyukhina, M. R. Bikbayeva, I. A. Sakhnova, M. A. Suchkov, E. A. Zaytseva   +5 more
doaj   +1 more source