Results 151 to 160 of about 80,797 (377)
Advanced Science, EarlyView.Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang +16 more
wiley +1 more source
GDL: a model infrastructure for a regional digital library [PDF]
, 2002 This brief article describes the early days of the Glasgow Digital Library (GDL), when it was a cross-sectoral and city-wide collaborative initiative involving Strathclyde, Glasgow and Caledonian Universities, as well as Glasgow City Libraries and ...
Dawson, A., Macgregor, G., Nicholson, D.
core +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source
The effect of signal digitisation in CMB experiments
, 2003 Signal digitisation may produce significant effects in balloon - borne or space CMB experiments, since the limited bandwidth for downlink of data requires imposes a large quantisation step q applied on board by the instrument acquisition chain.
Balbi +19 more
core +1 more source
Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance
Advanced Science, EarlyView.By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam +6 more
wiley +1 more source
DIGITALIZATION OF INHERITANCE DOCUMENTS
ACROSSThe digitisation of inheritance documents has become a topic of essential interest in the context of modernising legal processes and increasing administrative efficiency.
Gabriel Florinel ION +1 more
doaj +1 more source
STELLAR (Semantic Technologies Enhancing the Lifecycle of Learning Resources): Jisc Final Report [PDF]
, 2013 [Project Summary] As one of the earliest distance learning providers The Open University (OU) has a rich heritage of archived learning materials. An ever increasing amount of that is in digital form and is being deposited with the University Archive ...
Brown, Sarah, Nurse, Richard
core
Advanced Science, EarlyView.This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme +12 more
wiley +1 more source