Results 151 to 160 of about 95,335 (335)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Digitisation as archival intermediary: Quantifying and qualifying Greta B. Stevenson's mycological collector networks

open access: yesPlants, People, Planet
Societal Impact Statement Mass digitisation of natural science collections and archives has increasingly become a priority for scientific heritage institutions.
Christopher Kreuzer   +2 more
doaj   +1 more source

Digitised Diseases

open access: yesThe Bulletin of the Royal College of Surgeons of England, 2013
Over the past year RCS museum staff have been working on a project called Digitised Diseases. This Joint Information Systems Committee (JISC)-funded project is a collaboration with the university of Bradford and Museum of London Archaeology (MOLA). Digitised Diseases aims to bridge the gap between modern clinical medicine, historic medical collections
openaire   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

open access: yesAdvanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie   +10 more
wiley   +1 more source

Digitisation: taking stock

open access: yes, 2004
The technicalities of digitisation are now fairly well understood, but what is less well understood is the range of issues that need to be considered before committing to a digitisation programme, if it is not to meet the fate of the BBC Doomsday Project.
Currall, J   +3 more
core   +1 more source

Digitise This! Innovation in Digitisation Initiatives within Australasian Herbaria

open access: yes, 2018
Significant progress has been made in the last 10 years towards provision of digital data and images of the more than 8.0 million specimens in Australian and New Zealand herbaria. Initial investments of equipment, funding for salaries and development of protocols, led by the Journal Storage (JSTOR) Global Plants Initiative (GPI), with generous support ...
Ranatunga,Dhahara   +2 more
openaire   +2 more sources

Large‐Area Noise‐Resilient Multiplexing Triboelectric Biomechanical Sensing on Clothing for High‐Precision Full‐Body Motion Capture in Wearables

open access: yesAdvanced Science, EarlyView.
A large‐area, noise‐resilient multiplexed triboelectric sensing garment based on a multilayer shielded architecture and SnS2 nanoflower‐engineered hybrid materials enables interference‐suppressed, high‐fidelity full‐body motion tracking, achieving 0.13% signal misrecognition, 57 dB electromagnetic noise attenuation, and >1.5 N threshold force, while ...
Beibei Shao   +14 more
wiley   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

open access: yesAdvanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang   +10 more
wiley   +1 more source

Impact of Copyright Law on Mass Digitisation

open access: yes, 2019
Digitisation plays a major role in preserving the information artefact. Works held in national archives, libraries and museums worldwide are increasingly being digitised, thereby generating greater financial rewards for copyright owners through the use ...
Adesanya, Olumayowa   +1 more
core  

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

open access: yesAdvanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan   +10 more
wiley   +1 more source

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