Results 101 to 110 of about 10,900 (273)

Three-dimensional structure of human serum albumin [PDF]

The binding locations to human serum albumin (HSA) of several drug molecules were determined at low resolution using crystallographic methods. The principal binding sites are located within subdomains IIA and IIIA.
Carter, Daniel C., Casale, Elena, He, Xiao-Min, Twigg, Pamela D.   +3 more
core   +1 more source

Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Toxins, 2020
Cardiac glycosides (CGs) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to develop a targeted analytical method utilizing liquid chromatography—tandem mass spectrometry (LC-MS/MS) for
Svetlana V. Malysheva, Patrick P. J. Mulder, Julien Masquelier   +2 more
doaj   +1 more source

The dual role of cellular senescence in human tumor progression and therapy

MedComm, Volume 5, Issue 9, September 2024.
The study of cellular senescence is a long process, and people continue to explore new mechanisms to improve the role of cellular senescence in cancer, and now we can judge that cellular senescence plays different roles in a variety of cancers, and its duality in cancer requires the attention of doctors and researchers.
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan   +8 more
wiley   +1 more source

Left atrial low‐voltage areas, but not volume, predict the recurrence of atrial fibrillation in repeat ablation procedures

Journal of Cardiovascular Electrophysiology, Volume 35, Issue 6, Page 1156-1164, June 2024.
The amount of left atrial low voltage areas (LVA) rather than left atrial volume predicts arrhythmia recurrence in repeat ablation on procedures. A thorough 3‐D mapping and LVA assessment of the left atrium should be accomplished by default to optimize patient selection for further interventions. Abstract Introduction Left atrial (LA) low voltage areas
Christian Georgi, Marwin Bannehr, Marlene Lochmann, David Reiners, Anja Haase‐Fielitz, Christian Butter, Martin Seifert   +6 more
wiley   +1 more source

Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression

Journal of Carcinogenesis, 2013
Background: Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not known. It has been reported that
Qingfeng Yang, C. Dalgard, O. Eidelman, C. Jozwik, B. Pollard, M. Srivastava, H. Pollard   +6 more
semanticscholar   +1 more source

Evaluation of chromosome abberations induced by digoxin in Chinese hamster ovary cells [PDF]

, 2013
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells.
Saadat, Iraj, Saadat, Mostafa, Sedigh-Ardekani, Mozhgan   +2 more
core  

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B.

RNA: A publication of the RNA Society, 2012
Modulation of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human diseases. We investigated the mechanism by which digitoxin, a member of the cardiotonic steroid class of drugs, regulates alternative ...
Erik S Anderson, Chia-Ho Lin, Xinshu Xiao, P. Stoilov, C. Burge, D. Black   +5 more
semanticscholar   +1 more source

Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro [PDF]

, 2004
BACKGROUND: Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g. drugs) compounds.
Andersen, Anders, Børmer, Ole P, Kongsgaard, Ulf E, Nordbø, Arve, Olsen, Harald   +4 more
core   +2 more sources

Urinary Excretion of Digitoxin in the Rat.

Experimental Biology and Medicine, 1949
ConclusionA method for the quantitative determination of minute amounts of digitoxin in urine is described. The renal excretion of digitoxin is negligible in the rat.
Sanford O. Byers, Bine Rene, Meyer Friedman   +2 more
openaire   +3 more sources

Keep Your Guard Up: The Potential Impact of Drug Shortages on Pharmacoepidemiological Studies

Pharmacoepidemiology and Drug Safety, Volume 33, Issue 10, October 2024.
Araniy Santhireswaran, Emma Bjørk, Hanin Harbi, Mina Tadrous, Anton Pottegård   +4 more
wiley   +1 more source