Results 101 to 110 of about 10,909 (272)

Efficacy and safety of low‐dose digoxin in patients with heart failure. Rationale and design of the DECISION trial

European Journal of Heart Failure, Volume 26, Issue 10, Page 2223-2230, October 2024.
Rationale and design of the DECISION trial. ECG, electrocardiogram; HF, heart failure; LVEF, left ventricular ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association. Abstract Aims Digoxin is the oldest drug in cardiovascular (CV) medicine, and one trial conducted >25 years ago showed a reduction in ...
Dirk J. van Veldhuisen, Michiel Rienstra, Arend Mosterd, A. Marco Alings, Antoinette D.J. van Asselt, Marcel L Bouvy, Jan G.P. Tijssen, Jeroen Schaap, Ernst E. van der Wall, Adriaan A. Voors, Eva M. Boorsma, Dirk J.A. Lok, Harry J.G.M. Crijns, Astrid Schut, Marlene A.T. Vijver, Geert H.D. Voordes, Agaath H. de Vos, Ester L. Maas‐Soer, Nicoline W. Smit, Daan J. Touw, Michelle Samuel, Peter van der Meer, DECISION Investigators and Committees, Dirk J. van Veldhuisen, Peter van der Meer, Michiel Rienstra, Arend Mosterd, Marco Alings, Jan Tijssen, Thea van Asselt, Marcel Bouvy, Ernst E. van der Wall, Jeroen Schaap, Adriaan A. Voors, Harry J. G. M. Crijns, Carlo Gaillard, Nick Veeger   +36 more
wiley   +1 more source

Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality

Therapeutics and Clinical Risk Management, 2017
Rasmus Rivinius,1 Matthias Helmschrott,1 Arjang Ruhparwar,2 Ann-Kathrin Rahm,1,3 Fabrice F Darche,1 Dierk Thomas,1 Tom Bruckner,4 Philipp Ehlermann,1 Hugo A Katus,1 Andreas O Doesch1,5 1Department of Cardiology, Angiology and Pneumology, Heidelberg ...
Rivinius R, Helmschrott M, Ruhparwar A, Rahm AK, Darche FF, Thomas D, Bruckner T, Ehlermann P, Katus HA, Doesch AO   +9 more
doaj  

Multi-spectroscopic investigation of the binding interaction of fosfomycin with bovine serum albumin

Journal of Pharmaceutical Analysis, 2015
The interaction between fosfomycin (FOS) and bovine serum albumin (BSA) has been investigated effectively by multi-spectroscopic techniques under physiological pH 7.4. FOS quenched the intrinsic fluorescence of BSA via static quenching.
Manjunath D. Meti, Sharanappa T. Nandibewoor, Shrinivas D. Joshi, Uttam A. More, Shivamurti A. Chimatadar   +4 more
doaj   +1 more source

Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Toxins, 2020
Cardiac glycosides (CGs) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to develop a targeted analytical method utilizing liquid chromatography—tandem mass spectrometry (LC-MS/MS) for
Svetlana V. Malysheva, Patrick P. J. Mulder, Julien Masquelier   +2 more
doaj   +1 more source

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Three-dimensional structure of human serum albumin [PDF]

The binding locations to human serum albumin (HSA) of several drug molecules were determined at low resolution using crystallographic methods. The principal binding sites are located within subdomains IIA and IIIA.
Carter, Daniel C., Casale, Elena, He, Xiao-Min, Twigg, Pamela D.   +3 more
core   +1 more source

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages [PDF]

, 2013
Background HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory ...
Gerk, Phillip M., Hylemon, Phillip B., Liu, Xuyuan, Pandak, William M., Jr., Shi, Jian, Studer, Elaine, Wang, Guangji, Wang, Yun, Xu, Weiren, Zha, Beth S., Zha, Weibin, Zhao, Qijin, Zhou, Huiping   +12 more
core   +4 more sources

Thermodynamic and structural studies on the human serum albumin in the presence of a polyoxometalate [PDF]

The interaction of a polyoxometal (POM), K₆SiW ₁₁Co(H₂O)O₃₉.10H₂O (K₆) as a Keggin, with human serum albumin (HSA ...
امانی, مجتبی, بهنام, حسین, حسنی, زهرا, رنجبر, بیژن, صبوری, علی اکبر, عاجلو, داوود, علیزاده, کمال, قرنفولی, محسن, محمدی زنوزی, فرخزاد, موسوی موحدی, علی اکبر   +9 more
core  

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression

Journal of Carcinogenesis, 2013
Background: Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not known. It has been reported that
Qingfeng Yang, C. Dalgard, O. Eidelman, C. Jozwik, B. Pollard, M. Srivastava, H. Pollard   +6 more
semanticscholar   +1 more source