Results 81 to 90 of about 4,113 (206)

腎臓のDigitoxin捕捉に関する研究 [PDF]

The isolated kidney of guinea pig was perfused with blood containing digitoxin, and the digitoxin uptake of kidney was determined by assaing the potency of perfusion fluid and overflow using guinea pigs.
筒井, 高紀
core   +2 more sources

High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants

Data in Brief, 2020
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi, Mary Grace E. Guardian, Rebecca Dickman, Zhen Q. Wang   +3 more
doaj   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Broadly Defined Antibiotic Adjuvants for Pseudomonas aeruginosa

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Pseudomonas aeruginosa is a widely distributed opportunistic pathogen with multiple drug resistance, making it particularly challenging to treat in lower respiratory tract infections. Its resistance mechanisms are complex, including low outer‐membrane permeability, efflux pump overexpression, biofilm formation, and quorum sensing (QS) activation ...
Zhihan Chen, Yufan Li, Yuanlin Song, Jess Vergis   +3 more
wiley   +1 more source

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +1 more source

تاثير التشعيع والكولسترول والبروجسترون في انتاج المركبات الكلايكوسيدية القلبية من الافرع الخضرية لنبات الديجيتالس Digitalis lanata خارج الجسم الحي.

Journal of Kerbala for Agricultural Sciences, 2015
نفذ البحث في مختبر زراعة الانسجة النباتية/ كلية الزراعة/ جامعة بغداد للفترة من 1/11/2012 ولغاية عام 30/4/2014. اطراف الافرع بطول 2 سم التي تم الحصول عليها من الشتلات المعقمة لنبات Digitalis Lanata والمشععة بذورها بالجرع (0, 30) كري من اشعة كاما زرعت على
سراب عبد الهادي المختار, محمد شهاب حمد   +1 more
doaj   +1 more source

Drug–Drug Interaction Signals for Apixaban‐Associated Haemorrhage in Atrial Fibrillation and Thromboembolic Disorders: A Disproportionality Analysis of the FAERS Database

Journal of Interventional Cardiology, Volume 2026, Issue 1, 2026.
Background Apixaban is commonly used in anticoagulation therapy. Its safety profile is associated with polypharmacy and potential drug–drug interactions (DDIs). Current understanding often focuses on canonical metabolic pathways, while other biological factors of haemorrhagic risk remain not fully described.
Zhuang Chen, Zhi Li, Yuan Lu, Harleen Khatra   +3 more
wiley   +1 more source

Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality

Therapeutics and Clinical Risk Management, 2017
Rasmus Rivinius,1 Matthias Helmschrott,1 Arjang Ruhparwar,2 Ann-Kathrin Rahm,1,3 Fabrice F Darche,1 Dierk Thomas,1 Tom Bruckner,4 Philipp Ehlermann,1 Hugo A Katus,1 Andreas O Doesch1,5 1Department of Cardiology, Angiology and Pneumology, Heidelberg ...
Rivinius R, Helmschrott M, Ruhparwar A, Rahm AK, Darche FF, Thomas D, Bruckner T, Ehlermann P, Katus HA, Doesch AO   +9 more
doaj  

Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells

Digitoxin is used in the treatment of cardiac congestion and some types of cardiac arrhythmias. The mechanism of action of this cardiac glycoside suggested that it might antagonize the anticancer activity of topoisomerase II poisons.
Lopez-Lazaro M, Austin CA, Azrak SS, Ayuso MJ, Pastor N, Cortes F   +5 more
core   +4 more sources

Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach

Cancer Medicine
Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang   +8 more
doaj   +1 more source