Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics [PDF]
Biomolecules, 2021 Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well recognized and accepted in the treatment of various cardiac diseases as they can increase the rate ...
Ranjith Kumavath +2 more
exaly +4 more sources
Cardiac Glycosides as Autophagy Modulators [PDF]
Cells, 2021 Drug repositioning is one of the leading strategies in modern therapeutic research. Instead of searching for completely novel substances and demanding studies of their biological effects, much attention has been paid to the evaluation of commonly used ...
Jan Škubník +3 more
doaj +2 more sources
Na+/K+-ATPase as a Target of Cardiac Glycosides for the Treatment of SARS-CoV-2 Infection [PDF]
Frontiers in Pharmacology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified for the first time in Wuhan, China, causes coronavirus disease 2019 (COVID-19), which moved from epidemic status to becoming a pandemic.
Kauê Francisco Corrêa Souza e Souza +15 more
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Cardiac Glycosides as Immune System Modulators [PDF]
Biomolecules, 2021 Cardiac glycosides (CGs) are natural steroid compounds occurring both in plants and animals. They are known for long as cardiotonic agents commonly used for various cardiac diseases due to inhibition of Na+/K+-ATPase (NKA) pumping activity and modulating
Jan Škubník +2 more
doaj +2 more sources
Na+/K+-ATPase, cardiac glycosides, and tumor immunity [PDF]
Frontiers in ChemistryTumor immunity arises from the coordinated action of innate and adaptive immune systems but is hindered by immune escape within the immunosuppressive tumor microenvironment (TME), for which ion channels and ion pumps have proved to be important.
Yulin Ren +4 more
doaj +2 more sources
High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants [PDF]
Data in Brief, 2020 Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi +3 more
doaj +2 more sources
Anticancer and Immunogenic Properties of Cardiac Glycosides
Molecules, 2017 Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds.
Claudia Cerella +2 more
exaly +3 more sources
Cardiac Glycosides in Human Physiology and Disease: Update for Entomologists [PDF]
Insects, 2019 Cardiac glycosides, cardenolides and bufadienolides, are elaborated by several plant or animal species to prevent grazing or predation. Entomologists have characterized several insect species that have evolved the ability to sequester these glycosides in
Rif S. El-Mallakh +2 more
doaj +2 more sources
Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells [PDF]
Cardiology Research and Practice, 2019 Cardiac glycosides are a group of compounds widely known for their action in cardiac tissue, some of which have been found to be endogenously produced (ECG).
Alejandro Ogazon del Toro +6 more
doaj +2 more sources
Modern methods for identification and quantification of cardiac glycosides
Регуляторные исследования и экспертиза лекарственных средств, 2023 Scientific relevance. Cardiac glycosides have been used in medicine for over two centuries. Current studies suggest that biologically active substances from this group can be used to treat not only heart conditions but also viral infections, cancers, and
O. V. Evdokimova +6 more
doaj +1 more source