Results 1 to 10 of about 7,024 (237)

Cardenolides in the defensive fluid of adult large milkweed bugs have differential potency on vertebrate and invertebrate predator Na+/K+-ATPases [PDF]

Royal Society Open Science
Aposematic animals rely on diverse secondary metabolites for defence. Various hypotheses, such as competition, life history and multifunctionality, have been posited to explain defence variability and diversity.
P. Rubiano-Buitrago, S. Pradhan, A. A. Aceves, S. Mohammadi, C. Paetz, H. M. Rowland   +5 more
doaj   +3 more sources

Dietary cardenolides enhance growth and change the direction of the fecundity‐longevity trade‐off in milkweed bugs (Heteroptera: Lygaeinae)

Ecology and Evolution, 2021
Sequestration, that is, the accumulation of plant toxins into body tissues for defense, was predicted to incur physiological costs and may require resistance traits different from those of non‐sequestering insects.
Prayan Pokharel, Anke Steppuhn, Georg Petschenka   +2 more
doaj   +2 more sources

New Structures, Spectrometric Quantification, and Inhibitory Properties of Cardenolides from Asclepias curassavica Seeds

Molecules, 2022
Cardiac glycosides are a large class of secondary metabolites found in plants. In the genus Asclepias, cardenolides in milkweed plants have an established role in plant–herbivore and predator–prey interactions, based on their ability to inhibit the ...
Paola Rubiano-Buitrago, Shrikant Pradhan, Christian Paetz, Hannah M. Rowland   +3 more
doaj   +2 more sources

Differential accumulation of cardenolides from Asclepias curassavica by large milkweed bugs does not correspond to availability in seeds or biological activity on the bug Na+/K+-ATPase

Frontiers in Ecology and Evolution, 2023
Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago, Paola Rubiano-Buitrago, Shrikant Pradhan, Veit Grabe, Alfonso Aceves-Aparicio, Christian Paetz, Hannah M. Rowland   +6 more
doaj   +2 more sources

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus Alternaria eureka 1E1BL1: Characterization and Cytotoxic Activities

Molecules, 2021
Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir, Çiğdem Karakoyun, Gamze Doğan, Gülten Kuru, Melis Küçüksolak, Hasan Yusufoğlu   +5 more
doaj   +2 more sources

Cardenolide toxin diversity impacts monarch butterfly growth and sequestration [PDF]

eLife
In coevolutionary interactions, host plants accrue novel chemical defenses that specialist herbivores counter by detoxification and sometimes sequestration.
Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago   +2 more
doaj   +2 more sources

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]

Mol Ecol Resour
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
europepmc   +2 more sources

Rotation Conformational Effects of Selected Cytotoxic Cardiac Glycosides on Their Interactions with Na⁺/K⁺-ATPase [PDF]

Molecules
Cardenolides are an important group of steroidal natural products and have been used successfully for the treatment of cardiovascular diseases by targeting Na+/K+-ATPase (NKA) and found more recently to show potential anticancer activity.
Yulin Ren, Peirun Yang, Judith C. Gallucci, Can Wang, Xiaolin Cheng, Sijin Wu, A. Douglas Kinghorn   +6 more
doaj   +2 more sources

Defense of Milkweed Bugs (Heteroptera: Lygaeinae) against Predatory Lacewing Larvae Depends on Structural Differences of Sequestered Cardenolides

Insects, 2020
Predators and parasitoids regulate insect populations and select defense mechanisms such as the sequestration of plant toxins. Sequestration is common among herbivorous insects, yet how the structural variation of plant toxins affects defenses against ...
Prayan Pokharel, Marlon Sippel, Andreas Vilcinskas, Georg Petschenka   +3 more
doaj   +2 more sources

Pro-Apoptotic and Pro-Autophagic Properties of Cardenolides from Aerial Parts of Pergularia tomentosa

Molecules, 2022
Pergularia tomentosa L., a milkweed tropical plant belonging to the family Asclepiadaceae, is a rich source of unusual cardiac glycosides, characterised by transfused A/B rings and a sugar moiety linked by a double link, generating a dioxanoid structure.
Stefania Martucciello, Gaetana Paolella, Antonio Massimiliano Romanelli, Silvia Sposito, Lucia Meola, Antonietta Cerulli, Milena Masullo, Sonia Piacente, Ivana Caputo   +8 more
doaj   +2 more sources