Results 21 to 30 of about 2,370 (198)

Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species [PDF]

Molecules
Enzymes capable of processing a variety of compounds enable plants to adapt to diverse environmental conditions. PRISEs (progesterone-5β-reductase/iridoid synthase-like enzymes), examples of such substrate-promiscuous enzymes, are involved in iridoid and
Maja Dorfner, Jan Klein, Katharina Senkleiter, Harald Lanig, Wolfgang Kreis, Jennifer Munkert   +5 more
doaj   +2 more sources

Regionality and Temporal Dynamics of Sequestration and Relocation of Cardenolides in the Monarch Butterfly, Danaus plexippus. [PDF]

J Chem Ecol
The adaptation of monarch butterflies (Danaus plexippus) to milkweed plants and their ability to sequester toxic cardenolides is a model system for plant-herbivore coevolution.
Betz A, Höglinger B, Walker F, Petschenka G.   +3 more
europepmc   +2 more sources

Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander

iScience, 2022
Summary: Apocynaceae plants produce toxic cardenolides to defend against their herbivores. Cardenolides could inhibit the α subunit of Na+⁄K+-ATPase (ATPα), which plays critical roles in biological processes such as muscle contraction, neural function ...
Tianyu Wang, Lina Shi, Ying Zhen
doaj   +1 more source

Dietary cardenolides enhance growth and change the direction of the fecundity‐longevity trade‐off in milkweed bugs (Heteroptera: Lygaeinae)

Ecology and Evolution, 2021
Sequestration, that is, the accumulation of plant toxins into body tissues for defense, was predicted to incur physiological costs and may require resistance traits different from those of non‐sequestering insects.
Prayan Pokharel, Anke Steppuhn, Georg Petschenka   +2 more
doaj   +1 more source

High-resolution tandem mass spectrometry dataset reveals fragmentation patterns of cardiac glycosides in leaves of the foxglove plants

Data in Brief, 2020
Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi, Mary Grace E. Guardian, Rebecca Dickman, Zhen Q. Wang   +3 more
doaj   +1 more source

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus Alternaria eureka 1E1BL1: Characterization and Cytotoxic Activities

Molecules, 2021
Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir, Çiğdem Karakoyun, Gamze Doğan, Gülten Kuru, Melis Küçüksolak, Hasan Yusufoğlu   +5 more
doaj   +1 more source

Cardenolides and Derivatives

, 2022
There is growing interest in exploring Digitalis cardenolides as potential antiviral agents. Hence, we herein investigated the influence of structural features and lipophilicity on the antiherpes activity of 65 natural and semisynthetic cardenolides ...
Daniela Schuster, de Pádua, Rodrigo Maia, Vinícius Gonçalves Maltarollo, Wolfgang Kreis, Fernão Castro Braga, Kratz, Jadel Müller, Cláudia Maria Oliveira Simões, Munkert, Jennifer, Rigotto, Caroline, Braga, Fernão Castro, Kreis, Wolfgang, Simões, Cláudia Maria Oliveira, Schuster, Daniela, Maltarollo, Vinícius Gonçalves, Jadel Müller Kratz, Jennifer Munkert, Jéssica Wildgrube Bertol, Caroline Rigotto, Bertol, Jéssica Wildgrube, Rodrigo Maia de Pádua   +19 more
core   +1 more source

Defence mitigation by predators of chemically defended prey integrated over the predation sequence and across biological levels with a focus on cardiotonic steroids

Royal Society Open Science, 2022
Predator–prey interactions have long served as models for the investigation of adaptation and fitness in natural environments. Anti-predator defences such as mimicry and camouflage provide some of the best examples of evolution.
Shabnam Mohammadi, Lu Yang, Matthew Bulbert, Hannah M. Rowland   +3 more
doaj   +1 more source

Quo vadis Cardiac Glycoside Research?

Toxins, 2021
Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček, Michal Jurášek, Vojtěch Spiwok, Silvie Rimpelová   +3 more
doaj   +1 more source

Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo

Molecules, 2023
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth   +9 more
doaj   +1 more source