Results 21 to 30 of about 7,024 (237)
Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander
iScience, 2022 Summary: Apocynaceae plants produce toxic cardenolides to defend against their herbivores. Cardenolides could inhibit the α subunit of Na+⁄K+-ATPase (ATPα), which plays critical roles in biological processes such as muscle contraction, neural function ...
Tianyu Wang, Lina Shi, Ying Zhen
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Interactions between plants and herbivores constitute a major pathway of energy transfer up the food chain. As a consequence, evolution by natural selection has honed the chemically mediated antagonistic interactions between these groups ...
A. Agrawal +6 more
semanticscholar +1 more source
Royal Society Open Science, 2022 Predator–prey interactions have long served as models for the investigation of adaptation and fitness in natural environments. Anti-predator defences such as mimicry and camouflage provide some of the best examples of evolution.
Shabnam Mohammadi +3 more
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Data in Brief, 2020 Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi +3 more
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Quo vadis Cardiac Glycoside Research?
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
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Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Molecules, 2023 Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan +9 more
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Unraveling the roles of genotype and environment in the expression of plant defense phenotypes
Ecology and Evolution, 2021 Phenotypic variability results from interactions between genotype and environment and is a major driver of ecological and evolutionary interactions. Measuring the relative contributions of genetic variation, the environment, and their interaction to ...
Abigail S. Potts, Mark D. Hunter
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Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]
, 2015 PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David +13 more
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Characterization and Chromatographic Fingerprint Analysis of Traditional Wallflower Oil [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: Wallflower oil is made from the flowers of Erysimum cheiri (L.) Crantz which is a herb rich in cardenolide compounds. Wallflower oil was traditionally indicated for analgesic, anti-inflammatory, hair tonic, and wound healing ...
Ghazaleh Mosleh +2 more
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Consequences of toxic secondary compounds in nectar for mutualist bees and antagonist butterflies [PDF]
, 2016 Attraction of mutualists and defense against antagonists are critical challenges for most organisms and can be especially acute for plants with pollinating and non?pollinating flower visitors.
Agrawal, Anurag A., Jones, Patricia L.
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