Results 21 to 30 of about 1,646 (174)

Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo

Molecules, 2023
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth   +9 more
doaj   +1 more source

LC-MS-based metabolite profiling of aqueous extract of Pergularia tomentosa L. and its anti-hyperglycemic effect [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): In this study, to find scientific evidence for the traditional use of Pergularia tomentosa as an anti-diabetic remedy, the effects of its aqueous extract on streptozotocin-induced diabetes mellitus in rats were evaluated.Materials and ...
Seyed Hamzeh Hosseini, Fereshteh Ezzati Ghadi, Abdollah Ramzani Ghara, Antonietta Cerulli, Abolfazl Shakeri, Sonia Piacente   +5 more
doaj   +1 more source

Antiproliferative activity of standardized herbal phytopreparation from Asclepias subulata [version 2; peer review: 2 approved, 1 not approved]

F1000Research, 2022
Background: Several studies have shown that active compounds of Asclepias subulata (cardenolides) have antiproliferative effect on human cancer cells. Cardenolides isolated from A.
Wagner Vilegas, Carlos Velazquez, Ramón Enrique Robles Zepeda, Salvador Enrique Meneses Sagrero, Luisa Alondra Rascón Valenzuela, Olivia Valenzuela Antelo, Francisco Humberto González Gutiérrez, Marcelo J. Dias-Silva   +7 more
doaj   +1 more source

Avaliação quantitativa de cardenolídeos no cultivar experimental de Digitalis lanata do maciço do itatiaia e perspectivas de seu emprego industrial Quantitative evaluation of cardenolides in a brazilian digitalis lanata cultivar and perspectives of its industrial use

Química Nova, 1997
The content of digoxin and lanatoside C (jointly quantified), lanatoside A, lanatoside B, glucoevatromonoside, odorobioside G, glucogitoroside, glucoverodoxine, glucodigifucoside and digitalinum verum was determined by HPLC in Digitalis lanata harvested ...
Fernão Castro Braga, Wolfgang Kreis, Rubens Almeida Récio, Alaíde Braga de Oliveira   +3 more
doaj   +1 more source

Independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

eLife, 2020
Phytochemical diversity is thought to result from coevolutionary cycles as specialization in herbivores imposes diversifying selection on plant chemical defenses.
Tobias Züst, Susan R Strickler, Adrian F Powell, Makenzie E Mabry, Hong An, Mahdieh Mirzaei, Thomas York, Cynthia K Holland, Pavan Kumar, Matthias Erb, Georg Petschenka, José-María Gómez, Francisco Perfectti, Caroline Müller, J Chris Pires, Lukas A Mueller, Georg Jander   +16 more
doaj   +1 more source

Unraveling the roles of genotype and environment in the expression of plant defense phenotypes

Ecology and Evolution, 2021
Phenotypic variability results from interactions between genotype and environment and is a major driver of ecological and evolutionary interactions. Measuring the relative contributions of genetic variation, the environment, and their interaction to ...
Abigail S. Potts, Mark D. Hunter
doaj   +1 more source

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources

The function and evolutionary significance of a triplicated Na,K-ATPase gene in a toxin-specialized insect

BMC Evolutionary Biology, 2017
Background The Na,K-ATPase is a vital animal cell-membrane protein that maintains the cell’s resting potential, among other functions. Cardenolides, a group of potent plant toxins, bind to and inhibit this pump.
Jennifer N. Lohr, Fee Meinzer, Safaa Dalla, Renja Romey-Glüsing, Susanne Dobler   +4 more
doaj   +1 more source

Defense of Milkweed Bugs (Heteroptera: Lygaeinae) against Predatory Lacewing Larvae Depends on Structural Differences of Sequestered Cardenolides

Insects, 2020
Predators and parasitoids regulate insect populations and select defense mechanisms such as the sequestration of plant toxins. Sequestration is common among herbivorous insects, yet how the structural variation of plant toxins affects defenses against ...
Prayan Pokharel, Marlon Sippel, Andreas Vilcinskas, Georg Petschenka   +3 more
doaj   +1 more source

Bioactive Compounds from the Plants of the Elaeodendron Genus and Their Biological Activities—A Review

Applied Sciences, 2022
Elaeodendron is a genus of tiny trees, shrubs, vines, and herbs consisting of about 23 species. It is used in traditional medicine and has a wide range of pharmacological activities.
Nambooze Jennifer, Abhay Prakash Mishra, Manisha Nigam, Hari Prasad Devkota, Keshav Raj Paudel, Motlalepula Gilbert Matsabisa   +5 more
doaj   +1 more source