Quo vadis Cardiac Glycoside Research? [PDF]
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
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Antidote use for cardiac arrest or hemodynamic instability due to cardiac glycoside poisoning: A narrative review [PDF]
Resuscitation PlusIntroduction: Cardiac glycosides comprise medications such as digoxin and digitoxin, plants, and even certain toad venoms. Intoxication with cardiac glycosides can lead to hemodynamic instability and cardiac arrest.
Jessie Beaulieu, Maude St-Onge
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Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo [PDF]
eLife, 2019 Predicting how species will respond to selection pressures requires understanding the factors that constrain their evolution. We use genome engineering of Drosophila to investigate constraints on the repeated evolution of unrelated herbivorous insects to
Andrew M Taverner +12 more
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Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3 [PDF]
Frontiers in Oncology, 2021 Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du +5 more
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The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. [PDF]
PLoS ONE, 2017 Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment and ...
Motoi Kobayashi +9 more
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Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death [PDF]
Frontiers in Pharmacology, 2018 Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart diseases. Recent investigations repositioned CGs as potential anticancer agents.
Naira F. Z. Schneider +17 more
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Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death [PDF]
Molecules, 2016 Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng +3 more
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The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner [PDF]
Molecular Genetics and Metabolism Reports, 2017 Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood.
Sarah E. Anderson, Christopher E. Barton
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Subcellular localization of enzymes involved in the biosynthesis of digoxin in Digitalis lanata [PDF]
Frontiers in Plant ScienceDigoxin is a cardiac glycoside derived from the foxglove plant Digitalis lanata and is widely prescribed for treating heart failure and atrial fibrillation.
Viviane Zeng +3 more
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Cardiac glycosides in patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular MedicineBackgroundThe prognostic benefits of cardiac glycosides in patients with heart failure and reduced ejection fraction (HFrEF) remain controversial. Although digitoxin exhibits more favorable pharmacokinetic characteristics than digoxin, its potential to ...
Dayang Wang +7 more
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