Results 41 to 50 of about 28,908 (220)

Infused Tiger Nut and Almond Nut Crunchy Snacks Enhanced the Nutritional Value and Antioxidant Activity in High‐Fat Diet Fed Rat

Food Chemistry International, EarlyView.
Crunches were produced from formulations of almond nuts and tiger nuts (AN–TN) for the plausible management of commodity disease of obese condition. The produced AN–TN crunches showed high consumers acceptability, phenolic, and amylopectin contents. In addition, formulated percentages of AN–TN crunches when fed to high‐fat diet (HFD) fed rats led to ...
Olufunke Florence Ajeigbe, Ayokunle Olubode Ademosun, Ganiyu Oboh, Oluwatobi Emmauel Allen, Bolaji Lawrence Awe   +4 more
wiley   +1 more source

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]

, 2013
A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G., Ginet, V., Green, D.R., Levine, B., Liu, Y., Posner, B., Puyal, J., Shaw, S.Y., Shoji-Kawata, S., Sumpter, R.M., Tran, K.A., Wei, Y., Xavier, R.J., Zhang, L.   +13 more
core   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Atrial standstill in a horse with cardiac glycoside intoxication [PDF]

, 2012
C
De Clercq, Dominique, Decloedt, Annelies, Lefère, Laurence, van Loon, Gunther, Verheyen, Tinne   +4 more
core   +1 more source

Epidemiology, prehospital care and outcomes of patients arriving by ambulance with dyspnoea: An observational study [PDF]

, 2016
Background: This study aimed to determine epidemiology and outcome for patients presenting to emergency departments (ED) with shortness of breath who were transported by ambulance.
Archer, Peter, Asha, Stephen Edward, Bryant, Michael, Chalkley, Dane, Chan, Barry, Cheri, Thomas, Chor, Melvin S Y, Cowell, David Lord, Craig, Simon, De Villecourt, Tracey, Duffy, Martin, Eley, Rob, Furyk, Jeremy, Goh, Shaun E., Graham, Colin A., Grummisch, Michelle, Haythorne, Helen, Holdgate, Anna, Jain, Nitin, Jones, Peter, Keijzers, Gerben, Kelly, Anne Maree, Kinnear, Frances, Klim, Sharon, Knott, Jonathan, Kuan, Win Sen, Laribi, Said, Lawoko, Charles, Lee, Francis Chun Yue, Lee, Kendall, Lee, Wee Yee, Leung, Ling Pong, Lozzi, Lydia, MacDonald, Stephen, Mahlangu, Mlungisi, Man, Chan Ka, Martin, Shane, McNulty, Richard, Meek, Robert, Morel, Douglas Gordon, Nguyen, Mai, Orda, Ulrich, Rahman, Nik Hisamuddin, Ritchie, Peter, Rosengarten, Pamela, Rosengren, David, Russell, Kerrie, Ryan, Alison, Saiboon, Ismail Mohd, Scott, Michael, Smith, Richard D B, Thom, Ogilvie, Thone, Jae, Watkins, Gina, Watson, Michael, Wilson, Kathryn, Wong, Chi Pang, Wong, Tai Wai   +57 more
core   +2 more sources

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

EFFECT OF PROCESSING ON THEVETIA PERUVIANA GLYCOSIDE

The Bioscientist, 2014
The nutritional content of the meal of Thevetia peruviana seed is comparable to that of soybean and peanut meals but is rarely consumed due to its toxicity, resulting from high content of cardiac glycoside.
V. Markus, M.S. Abdulsalami, M Mustapha, A.A. Malik   +3 more
doaj  

Structural Insights into the Interactions of Digoxin and Na⁺/K⁺-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

Molecules, 2021
Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the ...
Yulin Ren, Sijin Wu, Joanna E. Burdette, Xiaolin Cheng, A. Douglas Kinghorn   +4 more
doaj   +1 more source