BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin. [PDF]
J Neurosci, 2014 We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro and in vivo brain slice-based models for focal ischemia (Dunn et al., 2011).
Van Kanegan MJ +6 more
europepmc +2 more sources
Pharmacological treatment of cardiac glycoside poisoning. [PDF]
Br J Clin Pharmacol, 2016 Roberts DM +3 more
europepmc +2 more sources
Cardiac glycosides in patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular MedicineBackgroundThe prognostic benefits of cardiac glycosides in patients with heart failure and reduced ejection fraction (HFrEF) remain controversial. Although digitoxin exhibits more favorable pharmacokinetic characteristics than digoxin, its potential to ...
Dayang Wang +7 more
doaj +2 more sources
A Fatal Case of Suicide Fruit Ingestion in Singapore by Cerbera Cardiac Glycoside Intoxication: Case Report and Review of Literature [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Case Presentation: We present a case of Cerbera fruit ingestion which highlight the knowledge gap in unusual glycoside poisoning. Despite the patient’s asymptomatic presentation, life threatening clinical features such as hyperkalaemia, hypotension and ...
Yee Shay Lee +3 more
doaj +1 more source
Antitumor Activity of the Cardiac Glycoside αlDiginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells [PDF]
International Journal of Molecular Sciences, 2020 Chia-Hsien Feng +2 more
exaly +2 more sources
Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 [PDF]
PeerJ, 2020 Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for ...
Jui-Tung Liu +3 more
doaj +2 more sources
Pharmacological aspects of acute treatment glycoside intoxication
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021 Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling +2 more
doaj +1 more source
Cardiac Glycosides and Cardiomyopathy [PDF]
Hypertension, 2006 Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
openaire +4 more sources
Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Molecules, 2023 Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan +9 more
doaj +1 more source
Activated charcoal hemadsorption in Cerbera odollam poisoning
Apollo Medicine, 2022 Cerbera odollam belongs to the poisonous Apocynaceae family, which grows in coastal salt swamps, creeks and along river banks found in South India. The poisonous part of the plant is the kernel containing the toxin cerberin which is a cardiac glycoside ...
Dyna Jones +3 more
doaj +1 more source