Results 21 to 30 of about 20,846 (206)
Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 [PDF]
PeerJ, 2020 Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for ...
Jui-Tung Liu +3 more
doaj +2 more sources
Pharmacological aspects of acute treatment glycoside intoxication
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021 Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling +2 more
doaj +1 more source
Cardiac Glycosides and Cardiomyopathy [PDF]
Hypertension, 2006 Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
openaire +4 more sources
Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Molecules, 2023 Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan +9 more
doaj +1 more source
Activated charcoal hemadsorption in Cerbera odollam poisoning
Apollo Medicine, 2022 Cerbera odollam belongs to the poisonous Apocynaceae family, which grows in coastal salt swamps, creeks and along river banks found in South India. The poisonous part of the plant is the kernel containing the toxin cerberin which is a cardiac glycoside ...
Dyna Jones +3 more
doaj +1 more source
Cells, 2023 The synergy between Na+-K+ pumps, Na+-Ca2+ exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs).
Sofia Segal, Yael Yaniv
doaj +1 more source
Antitumor Activity of the Cardiac Glycoside αlDiginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells. [PDF]
Int J Mol Sci, 2020 We recently isolated a cardiac glycoside (CG), αldiginoside, from an indigenous plant in Taiwan, which exhibits potent tumor-suppressive efficacy in oral squamous cell carcinoma (OSCC) cell lines (SCC2095 and SCC4, IC50 < 0.2 µM; 3-(4,5 ...
Weng JR, Lin WY, Bai LY, Hu JL, Feng CH.
europepmc +2 more sources
(+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks. [PDF]
J Nat Prod, 2017 (+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent.
Chen WL +8 more
europepmc +2 more sources
PHARMACOLOGICAL CORRECTION OF DILATED CARDIOMYOPATHY IN DOGS
Ветеринарная патология, 2021 In the practice of treating small domestic animals, cardiac diseases account for a signifcant part of cases of internal diseases of non-infectious etiology.
M. N. Lifentsova +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2023 Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago +6 more
doaj +1 more source