Inflammasome inhibition blocks cardiac glycoside cell toxicity [PDF]
Journal of Biological Chemistry, 2019 Chronic heart failure and cardiac arrhythmias have high morbidity and mortality, and drugs for the prevention and management of these diseases are a large part of the pharmaceutical market.
Doris L Larock +2 more
exaly +4 more sources
Onderstepoort Journal of Veterinary Research, 2005 Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz +2 more
doaj +3 more sources
Cardiac Glycoside Plants Self-Poisoning
Acta Medica Bulgarica, 2014 Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander, Convallaria majalis (lily of the valley), Strophanthus gratus, etc.
Radenkova-Saeva J., Atanasov P.
doaj +2 more sources
CARDIAC GLYCOSIDES IN UP-TO-DATE CLINICAL PRACTICE
Alʹmanah Kliničeskoj Mediciny, 2016 The article reviews the use of cardiac glycosides in patients with chronic heart failure, paroxysmal tachyarrhythmia and chronic atrial fibrillation (rate control).
M. A. Gurevich, A. A. Gavrilin
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The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. [PDF]
J Nat Prod, 2023 A cardiac glycoside epoxide, (−)-cryptanoside A (1), was isolated from the stems of Cryptolepis dubia collected in Laos, for which the complete structure was confirmed by analysis of its spectroscopic and single-crystal X-ray diffraction data, using ...
Ren Y +11 more
europepmc +3 more sources
Convergent evolution of cardiac-glycoside resistance in predators and parasites of milkweed herbivores. [PDF]
Curr Biol, 2021 The community of plant-feeding insects (herbivores) that specialize on milkweeds (Apocynaceae) form a remarkable example of convergent evolution across levels of biological organization1.
Groen SC, Whiteman NK.
europepmc +2 more sources
Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase. [PDF]
Invest Ophthalmol Vis Sci, 2020 PURPOSE. Mutations in the RS1 gene, which encodes retinoschisin, cause X-linked juvenile retinoschisis, a retinal dystrophy in males. Retinoschisin specifically interacts with the retinal sodium-potassium adenosine triphosphatase (Na/K-ATPase), a ...
Schmid V +5 more
europepmc +2 more sources
Cardiac glycosides in patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular MedicineBackgroundThe prognostic benefits of cardiac glycosides in patients with heart failure and reduced ejection fraction (HFrEF) remain controversial. Although digitoxin exhibits more favorable pharmacokinetic characteristics than digoxin, its potential to ...
Dayang Wang +7 more
doaj +2 more sources
A Fatal Case of Suicide Fruit Ingestion in Singapore by Cerbera Cardiac Glycoside Intoxication: Case Report and Review of Literature [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Case Presentation: We present a case of Cerbera fruit ingestion which highlight the knowledge gap in unusual glycoside poisoning. Despite the patient’s asymptomatic presentation, life threatening clinical features such as hyperkalaemia, hypotension and ...
Yee Shay Lee +3 more
doaj +1 more source
The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways. [PDF]
Cancers (Basel), 2021 Prostate cancer (PCa) is a leading cause of cancer-related deaths among men worldwide, and novel therapies for advanced PCa are urgently needed. Cardiac glycosides represent an attractive group of candidates for anticancer repurposing, but the cardiac ...
Liu M +6 more
europepmc +2 more sources