A Fatal Case of Suicide Fruit Ingestion in Singapore by Cerbera Cardiac Glycoside Intoxication: Case Report and Review of Literature [PDF]
Case Presentation: We present a case of Cerbera fruit ingestion which highlight the knowledge gap in unusual glycoside poisoning. Despite the patient’s asymptomatic presentation, life threatening clinical features such as hyperkalaemia, hypotension and ...
Yee Shay Lee +3 more
doaj +1 more source
Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 [PDF]
Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for ...
Jui-Tung Liu +3 more
doaj +2 more sources
Pharmacological aspects of acute treatment glycoside intoxication
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling +2 more
doaj +1 more source
Cardiac Glycosides and Cardiomyopathy [PDF]
Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
openaire +3 more sources
Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan +9 more
doaj +1 more source
Activated charcoal hemadsorption in Cerbera odollam poisoning
Cerbera odollam belongs to the poisonous Apocynaceae family, which grows in coastal salt swamps, creeks and along river banks found in South India. The poisonous part of the plant is the kernel containing the toxin cerberin which is a cardiac glycoside ...
Dyna Jones +3 more
doaj +1 more source
Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz +2 more
doaj +1 more source
The synergy between Na+-K+ pumps, Na+-Ca2+ exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs).
Sofia Segal, Yael Yaniv
doaj +1 more source
Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]
Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian +11 more
core +2 more sources
PHARMACOLOGICAL CORRECTION OF DILATED CARDIOMYOPATHY IN DOGS
In the practice of treating small domestic animals, cardiac diseases account for a signifcant part of cases of internal diseases of non-infectious etiology.
M. N. Lifentsova +3 more
doaj +1 more source

