Convergent evolution of cardiac-glycoside resistance in predators and parasites of milkweed herbivores. [PDF]
Curr Biol, 2021 In Brief Groen and Whiteman describe how convergently evolved substitutions in the Na+/K+-ATPase may have allowed a diverse set of natural enemies, including the black-headed grosbeak, to overcome the toxic cardiac glycosides sequestered by monarch ...
Groen SC, Whiteman NK.
europepmc +2 more sources
The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways. [PDF]
Cancers (Basel), 2021 Simple Summary Prostate cancer is a leading cause of cancer-related deaths among men, and novel therapies for advanced PCa are urgently needed. Cardiac glycosides are a group of attractive candidates for anticancer repurposing, but deslanoside has not ...
Liu M +6 more
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Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. [PDF]
Cell Death Dis, 2021 Chemotherapeutic agents have been linked to immunogenic cell death (ICD) induction that is capable of augmenting anti-tumor immune surveillance. The cardiac glycoside oleandrin, which inhibits Na+/K+-ATPase pump (NKP), has been shown to suppress breast ...
Li X +5 more
europepmc +2 more sources
Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase. [PDF]
Invest Ophthalmol Vis Sci, 2020 Purpose Mutations in the RS1 gene, which encodes retinoschisin, cause X-linked juvenile retinoschisis, a retinal dystrophy in males. Retinoschisin specifically interacts with the retinal sodium–potassium adenosine triphosphatase (Na/K-ATPase), a ...
Schmid V +5 more
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Comparative pharmacokinetics of periplocin and its four key metabolites in rats after oral administration of periplocin and cardiac glycoside extract from Cortex Periplocae [PDF]
Frontiers in PharmacologyIntroductionCortex Periplocae has been demonstrated to possess a variety of pharmacological effects, particularly in the treatment of chronic heart failure, attributed largely to its cardiac glycosides particularly periplocin.MethodsIn order to gain a ...
Peng Zhao +7 more
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(+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks. [PDF]
J Nat Prod, 2017 (+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent.
Chen WL +8 more
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Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. [PDF]
Sci Rep, 2018 The capacity of HIV-1 to develop resistance to current drugs calls for innovative strategies to control this infection. We aimed at developing novel inhibitors of HIV-1 replication by targeting viral RNA processing—a stage dependent on conserved host ...
Wong RW +4 more
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Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway. [PDF]
Oncotarget, 2018 In our previous study, cardiac glycosides including bufalin, a group of sodium pump (Na+/K+-ATPase) inhibitors widely used to treat heart failure for many years, have been demonstrated to induce a delay of mitotic entry and mitotic arrest in many cancer ...
Xie CM +6 more
europepmc +2 more sources
Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity. [PDF]
J Nat Prod, 2017 Three new (1–3) and two known (4 and 5) cytotoxic cardiac glycosides were isolated and characterized from a medicinal plant, Streblus asper, collected in Vietnam, with six new and one known derivatives (5a–5g) synthesized from (+)-strebloside (5).
Ren Y +13 more
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Transcriptome and Metabolite analysis reveal candidate genes of the cardiac glycoside biosynthetic pathway from Calotropis procera. [PDF]
Sci Rep, 2016 Calotropis procera is a medicinal plant of immense importance due to its pharmaceutical active components, especially cardiac glycosides (CG). As genomic resources for this plant are limited, the genes involved in CG biosynthetic pathway remain largely ...
Pandey A +6 more
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