Results 31 to 40 of about 764,918 (182)
Journal of Plant Protection Research, 2018 The tuber necrotic strain of Potato virus Y (PVYNTN) causes widespread disease and has severe negative effects on the growth and yields of plants, especially those of the Solanaceae family.
Simin Emamzadeh Yazdi +4 more
doaj +1 more source
Cardiac troponins in intensive care [PDF]
, 2005 The cardiac troponins are integral components of the myofibrillary apparatus and they regulate muscle contraction. The measurement of cardiac troponins has replaced other biomarkers for the specific detection of myocardial necrosis and for the diagnosis ...
Collinson, P.O. +3 more
core +1 more source
Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers
Frontiers in Oncology, 2020 Lung cancer is the most prevalent in cancer-related deaths, while breast carcinoma is the second most dominant cancer in women, accounting for the most number of deaths worldwide.
Dhanasekhar Reddy +2 more
doaj +1 more source
Advanced Science, EarlyView.Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan +9 more
wiley +1 more source
, 2016 The cardiac glycoside natural product digitoxin was selectively glycosylated at one of its five hydroxyl groups using a borinic acid derived catalyst.
Mark S. Taylor (611990) +1 more
core +1 more source
(+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks. [PDF]
J Nat Prod, 2017 (+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent.
Chen WL +8 more
europepmc +2 more sources
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
, 2020 Lignocellulolytic and chitinolytic glycoside hydrolases are commonly used enzymes in commercial processes and thus are well documented for their vital role in agriculture, textile, paper, food, biofuel and healthcare sectors. Ongoing research is targeted
Chawade, Aakash, +2 more
core +1 more source
Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition [PDF]
, 2019 Natural products possess a significant role in anticancer therapy and many currently-used anticancer drugs are of natural origin. Cerberin (CR), a cardenolide isolated from the fruit kernel of Cerbera odollam, was found to potently inhibit cancer cell ...
Wiart, Christophe +13 more
core +1 more source
AMB Express, 2020 Cardiac arrhythmia is an irregular heart rhythm that can lead to serious heart conditions and various organ disorders, and may cause sudden cardiac death.
Lingchao Yang +4 more
doaj +1 more source