Results 51 to 60 of about 764,918 (182)

Structural Insights into the Interactions of Digoxin and Na⁺/K⁺-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

Molecules, 2021
Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the ...
Yulin Ren, Sijin Wu, Joanna E. Burdette, Xiaolin Cheng, A. Douglas Kinghorn   +4 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Antihyperlipidemic effect of Adonis vernalis

Journal of the Dow University of Health Sciences, 2012
Objective To study the effect of Adonis vernalis on triton-induced hyperlipidemic rabbits. Hyperlipidemia has become a major risk factor for a large variety of diseases including coronary artery disease and thus increasing mortality ratio globally.
Tooba Lateef, Anila Riaz, Anum Zehra, Shamim A Qureshi   +3 more
doaj  

Medicinal Plants: A Public Resource for Metabolomics and Hypothesis Development

Metabolites, 2012
Specialized compounds from photosynthetic organisms serve as rich resources for drug development. From aspirin to atropine, plant-derived natural products have had a profound impact on human health.
Eve Syrkin Wurtele, Joe Chappell, A. Daniel Jones, Mary Dawn Celiz, Nick Ransom, Manhoi Hur, Ludmila Rizshsky, Philip Dixon, Jia Liu, Mark P. Widrlechner, Basil J. Nikolau   +10 more
doaj   +1 more source

A formulation‐driven plant‐derived nanoemulsion for root‐knot nematode control in tomato: efficacy across pot and greenhouse conditions

Pest Management Science, EarlyView.
Plant‐derived nanoemulsion for root‐knot nematode control in tomato: formulation concept, proposed mode of action, and efficacy under pot and greenhouse conditions. Abstract Objective Nanoemulsion‐based delivery systems offer a promising approach to improve the stability and biological performance of plant‐derived nematicides.
Ramanan Ganapathy, Ahmet Aykaç
wiley   +1 more source

Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.

, 2016
We have measured the effects of digoxin on the cation transport mechanisms of patients' erythrocytes during treatment with digoxin for atrial fibrillation and cardiac failure in sinus rhythm. The results show that during short-term treatment with digoxin

core   +1 more source

17βH-Neriifolin Improves Cardiac Remodeling Through Modulation of Calcium Handling Proteins in the Heart Failure Rat Model

Biomedicines
Background: Cardiac glycosides such as digoxin have been commonly used for patients with heart failure; however, their toxicity remains a main concern.
Rajasegar Anamalley, Yusof Kamisah, Nurhanan Murni Yunos, Satirah Zainalabidin   +3 more
doaj   +1 more source

Plant Toxins: Poison or Therapeutic?

CHIMIA, 2020
Many plants that are classed as poisonous also have therapeutic uses, and this is illustrated using members of the Drimia and Digitalis genera which are sources of cardiac glycosides.
Catherine E. Housecroft
doaj   +1 more source

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

Phytotherapy Research, EarlyView.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao, Da Ke, Jian Ni, Yuan Yuan, Zhang Nan, Xiujun Dai, Heng Zhou   +6 more
wiley   +1 more source