Results 71 to 80 of about 20,846 (206)

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

The effect of gamma ray and sugars on increasing the concentration of cardiac glycoside compounds of Digitalis lanata In vitro

, 2022
The Explants  that was used in the experiment to stimulate the production of glycoside compounds is the tips of the vegetative branches with a length of 2 cm obtained from the stage of vegetative multiplication growing from seeds treated with gamma ...
Sarab A. Almukhtar, Almukhtar, Sarab A.
core   +1 more source

Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection

mBio, 2016
Chikungunya virus (CHIKV) is a reemerging alphavirus that has caused epidemics of fever, arthralgia, and rash worldwide. There are currently no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV disease.
Alison W. Ashbrook, Anthony J. Lentscher, Paula F. Zamora, Laurie A. Silva, Nicholas A. May, Joshua A. Bauer, Thomas E. Morrison, Terence S. Dermody   +7 more
doaj   +1 more source

Gas Chromatography‐Mass Spectrometry‐Based Phytochemical Profiling and Bioactivity‐Guided Fractionation of Psidium guineense Stem Extracts: In Vitro and In Silico Insights Into Antioxidant, Antidiabetic and Antibacterial Potentials

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Psidium guineense (Myrtaceae) is traditionally used for various medicinal purposes, although its stem remains underexplored. This study provides the first integrated phytochemical, pharmacological and computational evaluation of the stem extracts to elucidate their antioxidant, antidiabetic and antibacterial potential.
Md. Jahid Hossain, Mst. Shagorika Shila, Muhammad Rashedul Islam, Jakir Ahmed Chowdhury   +3 more
wiley   +1 more source

Cardiac Glycosides Induce Resistance to Tubulin-Dependent Anticancer Drugs in Androgen-Independent Human Prostate Cancer

, 2009
Due to high prevalence and mortality and the lack of effective therapies, prostate cancer is one of the most crucial health problems in men. Drug resistance aggravates the situation, not only in human prostate cancer but also in other cancers.
CHUEH, SHIH-CHIEH;TENG, CHE-MING, 闕士傑;鄧哲明   +1 more
core  

Intoxication with Ornithogalum arabicum is a potential cause of visual impairment and irreversible blindness in dogs

Toxicon: X, 2019
We describe two dogs with persistent visual impairment after initially mild intoxication signs following ingestion of Ornithogalum arabicum plant material.
Inge J.M. Slenter, Sylvia C. Djajadiningrat-Laanen, Irma de Vries, Marieke A. Dijkman   +3 more
doaj   +1 more source

Infused Tiger Nut and Almond Nut Crunchy Snacks Enhanced the Nutritional Value and Antioxidant Activity in High‐Fat Diet Fed Rat

Food Chemistry International, Volume 2, Issue 2, Page 175-185, June 2026.
Crunches were produced from formulations of almond nuts and tiger nuts (AN–TN) for the plausible management of commodity disease of obese condition. The produced AN–TN crunches showed high consumers acceptability, phenolic, and amylopectin contents. In addition, formulated percentages of AN–TN crunches when fed to high‐fat diet (HFD) fed rats led to ...
Olufunke Florence Ajeigbe, Ayokunle Olubode Ademosun, Ganiyu Oboh, Oluwatobi Emmauel Allen, Bolaji Lawrence Awe   +4 more
wiley   +1 more source

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat

, 2010
pharmaceutic
Lowes, Simon, Anna-lena Ungell, Nicholas L. Simmons, Haslam, Iain S., Johan E. Karlsson, Iain S. Haslam, Ungell, Anna-Lena, Hilgendorf, Constanze, Ungell, Anna Lena, Simon Lowes, Fihn, Britt-Marie, Simmons, Nicholas L., Constanze Hilgendorf, Fihn, Britt Marie, Britt-marie Fihn, Karlsson, Johan E.   +15 more
core   +1 more source

The Composition and Biochemical Properties of Strophantus (Apocynaceae), with a Focus on S. sarmentosus

Molecules
The genus Strophantus belongs to the Apocynaceae family of flowering plants which grows primarily in tropical Africa. The plants are widely used in traditional herbal medicine. S. sarmentosus, in particular, is used for the treatment of, e.g., joint pain
Simone König
doaj   +1 more source

Improving Essential Oil, Pigments, and Mineral Accumulation in Basil Through Integrated Silicon and Nano‐Fertilizer Treatments in Aquaponics

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Combined Si and nano‐fertilizers enhanced basil growth and biomass. Essential oil, pigments, and mineral content significantly increased. Integrated nutrition improved yield and quality in aquaponic systems. ABSTRACT Innovative agricultural production systems and effective nutrient management approaches are essential to meet an escalating global demand
Al‐Hatem JihanYahya, AsmaaMohammed Adil, AliFarouq Al‐Ma'athedi, Heidar Meftahizade   +3 more
wiley   +1 more source