Results 61 to 70 of about 20,846 (206)

Antihyperlipidemic effect of Adonis vernalis

Journal of the Dow University of Health Sciences, 2012
Objective To study the effect of Adonis vernalis on triton-induced hyperlipidemic rabbits. Hyperlipidemia has become a major risk factor for a large variety of diseases including coronary artery disease and thus increasing mortality ratio globally.
Tooba Lateef, Anila Riaz, Anum Zehra, Shamim A Qureshi   +3 more
doaj  

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Antiviral Effects of Oleandrin

Journal of Experimental Pharmacology, 2020
Robert A Newman, 1, 2 K Jagannadha Sastry, 3 Ravit Arav-Boger, 4 Hongyi Cai, 5 Rick Matos, 6 Robert Harrod 7 1Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA; 2Phoenix Biotechnology,
Newman RA, Sastry KJ, Arav-Boger R, Cai H, Matos R, Harrod R   +5 more
doaj  

Plant Toxins: Poison or Therapeutic?

CHIMIA, 2020
Many plants that are classed as poisonous also have therapeutic uses, and this is illustrated using members of the Drimia and Digitalis genera which are sources of cardiac glycosides.
Catherine E. Housecroft
doaj   +1 more source

Ventilatory efficiency: Physiological modelling and mechanistic validation

The Journal of Physiology, EarlyView.
Abstract figure legend From post‐threshold ventilatory linearization to ceiling‐normalized efficiency – conceptual framework underlying ηV̇E$\eta {{\dot{V}}_{\mathrm{E}}}$ Conventional V̇E${{\dot{V}}_{\mathrm{E}}}$–V̇CO2${{\dot{V}}_{{\mathrm{C}}{{{\mathrm{O}}}_2}}}$ slopes are typically derived under submaximal conditions and may become physiologically
Paulo T Muller, Beate Stubbe, Till Ittermann, Erlandson S Ferreira, J A Neder, Ralf Ewert   +5 more
wiley   +1 more source

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

, 2010
International audienceCardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to investigate the anti-leukemic activity of UNBS1450, a semi-synthetic cardenolide belonging to the ...
Henry, Estelle, Marie-Hélène Teiten, Teiten, Marie-Hélène, Schumacher, Marc, Claudia Cerella, Cerella, Claudia, Schnekenburger, Michael, Franck Morceau, Michael Schnekenburger, Estelle Henry, Marc Schumacher, Tom Juncker, Morceau, Franck, Ghelfi, Jenny, Diederich, Marc, Juncker, Tom, Jenny Ghelfi, François Gaascht, Dicato, Mario, Mario Dicato, Marc Diederich   +20 more
core   +1 more source

Estimation of Tannin, Saponin, Oxalate, Cyanogenic and Cardiac Glycosides in Garsinia Kola

Journal of Applied Sciences and Environmental Management, 2004
The presence of some secondary plant metabolites — tannin, saponin, oxalate, cyanogenic and cardiac glycosides were done in Garsinia Cola. The tannin, saponin and oxalate content were 0.69 ± 0.01, 15.79 ± 0.28 and 1.707 ± 0.13mg/100g of dry sample ...
C.C. MONAGO, V. AKHIDUE
doaj   +1 more source

Substrate scope of ancestral versus modern family‐1 glycosidases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Experimental studies support that protein engineering based on ancestral sequence reconstruction often leads to variants with biotechnologically useful biomolecular properties. These may include high stability, enhanced conformational flexibility and a modified catalysis range.
Luis I. Gutierrez‐Rus, Dušan Petrović, Pascal Schneider, Katja Zorn, Gloria Gamiz‐Arco, Rocío Romero‐Zaliz, Ignacio Suarez‐Martin, Leonardo De Maria, Francesco Falcioni, Valeria A. Risso, Martin A. Hayes, Jose M. Sanchez‐Ruiz   +11 more
wiley   +1 more source

Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

, 2019
Natural products possess a significant role in anticancer therapy and many currently-used anticancer drugs are of natural origin. Cerberin (CR), a cardenolide isolated from the fruit kernel of Cerbera odollam, was found to potently inhibit cancer cell ...
Wiart, Christophe, Kagan, Leonid, Bradshaw, Tracey D., Chan, Zi-Yang, Collins, Hilary M., Khoo, Teng Jin, Lee, Jong Bong, Gershkovich, Pavel, Rahmatullah, Mohammed, Chan, Zi Yang, Shipton, Fiona N., Butler, Mark S., Hossan, Md Shahadat, Khoo, Teng-Jin   +13 more
core   +1 more source

Fatality Following Intentional Ingestion of Cerbera odollam Seeds

Clinical Practice and Cases in Emergency Medicine, 2018
Seeds from the mangrove plant Cerbera (C.) odollam, known as the “suicide tree,” are responsible for a significant number of plant deaths worldwide but are not well recognized in Western medicine. Cerberin is a cardiac glycoside concentrated in the plant’
Ryan Misek, Glenn Allen, Valerie LeComte, Nicholas Mazur   +3 more
doaj   +1 more source