Results 11 to 20 of about 2,772 (212)
Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
Molecules, 2015 A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (
Jae-Woo Jung +10 more
doaj +2 more sources
Química Nova, 1997 The content of digoxin and lanatoside C (jointly quantified), lanatoside A, lanatoside B, glucoevatromonoside, odorobioside G, glucogitoroside, glucoverodoxine, glucodigifucoside and digitalinum verum was determined by HPLC in Digitalis lanata harvested ...
Fernão Castro Braga +3 more
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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling. [PDF]
PLoS ONE, 2018 Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in ...
Martin Liss +6 more
doaj +2 more sources
Environment and Host Genetics Drive Infection Outcomes in a Butterfly Host, but Do Not Interact With Each Other. [PDF]
Ecol EvolThis study examined how host genetics and larval food plant environment influence parasite infection outcomes in monarch butterflies (Danaus plexippus) infected with the protozoan Ophryocystis elektroscirrha. We tested for genotype × environment interactions on infection status, infection burden, lifespan, and wing size.
Majewska AA, Chlebove G, de Roode JC.
europepmc +2 more sources
Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]
Mol Ecol ResourABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
europepmc +2 more sources
Cardenolides and Derivatives [PDF]
, 2022 There is growing interest in exploring Digitalis cardenolides as potential antiviral agents. Hence, we herein investigated the influence of structural features and lipophilicity on the antiherpes activity of 65 natural and semisynthetic cardenolides ...
Daniela Schuster +19 more
core +1 more source
Frontiers in Ecology and Evolution, 2023 Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago +6 more
doaj +1 more source
Data in Brief, 2020 Cardiac glycosides, steroid derivatives extracted from the foxglove plants, have been used for the treatment of heart failure since the 18th century. A method based on liquid chromatography coupled with high-resolution tandem mass spectrometry (LC/MS2 ...
Baradwaj Gopal Ravi +3 more
doaj +1 more source
Molecules, 2021 Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir +5 more
doaj +1 more source
Toxicity of Milkweed Leaves and Latex: Chromatographic Quantification Versus Biological Activity of Cardenolides in 16 Asclepias Species [PDF]
, 2019 Cardenolides are classically studied steroidal defenses in chemical ecology and plant-herbivore coevolution. Although milkweed plants (Asclepias spp.) produce up to 200 structurally different cardenolides, all compounds seemingly share the same well ...
Hastings, Amy P. +7 more
core +4 more sources