Results 11 to 20 of about 7,024 (237)

Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests [PDF]

Molecules
ATP-binding cassette (ABC) transporters, particularly those of subfamily B, are involved in cell detoxification, multidrug resistance, drug treatment pharmacodynamics, and also ecological adaptation.
Mario Röpcke, Sha Lu, Cäcilia Plate, Fee Meinzer, Antonia Lisiecki, Susanne Dobler   +5 more
doaj   +2 more sources

Secondary Compounds in Milkweed Nectar Negatively Impact Thermal Tolerance in Bumble Bees. [PDF]

Ecol Evol
This study shows that exposure to cardenolide toxins in floral nectar impacts heat tolerance in bumble bees at field‐realistic doses. Various honeys, aside from milkweed honey, did not impact heat tolerance in these bees. These data suggest that compounds in their diet may impact resilience of bees to global warming and that milkweed‐specialists may be
Shippee R, Feuerborn C, Bradley A, Jahnke H, Hines HM.   +4 more
europepmc   +2 more sources

Duckweeds: Model organisms for research on plant sterols and steroids. [PDF]

Plant Biol (Stuttg)
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
Klein J, Appenroth KJ, Sree KS.
europepmc   +2 more sources

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in an Erysimum cheiranthoides (Wormseed Wallflower) F2 Population [PDF]

Plants
Plants in the genus Erysimum produce both glucosinolates and cardenolides as a defense mechanism against herbivory. Two natural isolates of Erysimum cheiranthoides (wormseed wallflower) differed in their glucosinolate content, cardenolide content, and ...
Mahdieh Mirzaei, Gordon C. Younkin, Adrian F. Powell, Martin L. Alani, Susan R. Strickler, Georg Jander   +5 more
doaj   +2 more sources

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources

Total Synthesis of Cardenolides Acospectoside A and Acovenoside B [PDF]

Molecules
Acospectoside A (1) and acovenoside B (2), two cytotoxic cardenolides extracted from the venomous South African bush Acokanthera oppositifolia, are distinguished by their unique structural motifs of the l-acovenose moiety at C-3 and a 1β-O-acetylated ...
Benzhang Liu, Peng Xu, Biao Yu
doaj   +2 more sources

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

PLoS ONE, 2018
Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in ...
Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt   +6 more
doaj   +2 more sources

Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus [PDF]

Molecules
Strophanthus sarmentosus is recognised for various ethnomedicinal applications, including treatment after snakebites. However, only limited scientific evidence exists on its antivenomous capabilities.
Julius Abiola, Olapeju Aiyelaagbe, Akindele Adeyi, Babafemi Ajisebiola, Simone König   +4 more
doaj   +2 more sources

Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species [PDF]

Molecules
Enzymes capable of processing a variety of compounds enable plants to adapt to diverse environmental conditions. PRISEs (progesterone-5β-reductase/iridoid synthase-like enzymes), examples of such substrate-promiscuous enzymes, are involved in iridoid and
Maja Dorfner, Jan Klein, Katharina Senkleiter, Harald Lanig, Wolfgang Kreis, Jennifer Munkert   +5 more
doaj   +2 more sources