Results 1 to 10 of about 1,686 (179)

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]

Mol Ecol Resour
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
europepmc   +2 more sources

Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]

Small Methods
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M, Mifka A, de Pádua RM, da Silva IT, Guterres IZ, Sana L, Fuhrmann G, Munkert J.   +7 more
europepmc   +2 more sources

Cardenolide toxin diversity impacts monarch butterfly growth and sequestration. [PDF]

Elife
In coevolutionary interactions, host plants accrue novel chemical defenses that specialist herbivores counter by detoxification and sometimes sequestration.
Agrawal AA, Hastings AP, Rubiano-Buitrago P.   +2 more
europepmc   +2 more sources

Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in an Erysimum cheiranthoides (Wormseed Wallflower) F2 Population. [PDF]

Plants (Basel)
Plants in the genus Erysimum produce both glucosinolates and cardenolides as a defense mechanism against herbivory. Two natural isolates of Erysimum cheiranthoides (wormseed wallflower) differed in their glucosinolate content, cardenolide content, and ...
Mirzaei M, Younkin GC, Powell AF, Alani ML, Strickler SR, Jander G.   +5 more
europepmc   +2 more sources

Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin. [PDF]

Beilstein J Org Chem
Herein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable enzymatic C14–H
Song F, Zheng M, Wang D, Qu X, Zhou Q.
europepmc   +2 more sources

Thevetia thevetioides Cardenolide and Related Cardiac Glycoside Profile in Mature and Immature Seeds by High-Resolution Thin-Layer Chromatography (HPTLC) and Quadrupole Time of Flight-Tandem Mass Spectrometry (Q-TOF MS/MS) Reveals Insights of the Cardenolide Biosynthetic Pathway. [PDF]

Molecules
Thevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus.
Vázquez-Martínez J, Bravo-Villa P, Molina-Torres J.   +2 more
europepmc   +2 more sources

A New Cytotoxic 19-Nor-cardenolide from the Latex of Antiaris toxicaria

Molecules, 2009
A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR).
Wenli Mei, Shoubai Liu, Dai Hao-Fu
exaly   +3 more sources

The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells

Frontiers in Pharmacology, 2021
Cardenolide glycosides are natural compounds known to inhibit the ion pumping function of the Na+/K+-ATPase in cellular systems. Interestingly, various cancer cell types are highly susceptible to cardenolide glycosides. Herein, we explore the cardenolide
Susanne Hafner, Michael Schmiech, Sophia Johanna Lang   +2 more
doaj   +1 more source

Differential accumulation of cardenolides from Asclepias curassavica by large milkweed bugs does not correspond to availability in seeds or biological activity on the bug Na+/K+-ATPase

Frontiers in Ecology and Evolution, 2023
Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago, Paola Rubiano-Buitrago, Shrikant Pradhan, Veit Grabe, Alfonso Aceves-Aparicio, Christian Paetz, Hannah M. Rowland   +6 more
doaj   +1 more source

Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander

iScience, 2022
Summary: Apocynaceae plants produce toxic cardenolides to defend against their herbivores. Cardenolides could inhibit the α subunit of Na+⁄K+-ATPase (ATPα), which plays critical roles in biological processes such as muscle contraction, neural function ...
Tianyu Wang, Lina Shi, Ying Zhen
doaj   +1 more source