A New Cytotoxic 19-nor-Cardenolide From the Latex of Antiaris toxicaria
Molecules, 2009 A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR).
Wen-Li Mei, Shoubai Liu, Jiao Wu
exaly +4 more sources
Thevetia thevetioides Cardenolide and Related Cardiac Glycoside Profile in Mature and Immature Seeds by High-Resolution Thin-Layer Chromatography (HPTLC) and Quadrupole Time of Flight–Tandem Mass Spectrometry (Q-TOF MS/MS) Reveals Insights of the Cardenolide Biosynthetic Pathway [PDF]
MoleculesThevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus.
Juan Vázquez-Martínez +2 more
doaj +3 more sources
Frontiers in Pharmacology, 2021 Cardenolide glycosides are natural compounds known to inhibit the ion pumping function of the Na+/K+-ATPase in cellular systems. Interestingly, various cancer cell types are highly susceptible to cardenolide glycosides. Herein, we explore the cardenolide
Susanne Hafner +2 more
doaj +2 more sources
Anti-Neuroinflammatory Effects of Cardenolides in IL-1β-Activated SK-N-SH Cells [PDF]
MoleculesNeuroinflammation is a key feature of neurological disorders such as Alzheimer’s or Parkinson’s disease, depression or amyotrophic lateral sclerosis.
Lu Sun +6 more
doaj +2 more sources
Cardenolide toxin diversity impacts monarch butterfly growth and sequestration [PDF]
eLifeIn coevolutionary interactions, host plants accrue novel chemical defenses that specialist herbivores counter by detoxification and sometimes sequestration.
Anurag A Agrawal +2 more
doaj +2 more sources
Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin [PDF]
Beilstein Journal of Organic ChemistryHerein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable enzymatic C14–H
Fuzhen Song +4 more
doaj +2 more sources
Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in an Erysimum cheiranthoides (Wormseed Wallflower) F2 Population [PDF]
PlantsPlants in the genus Erysimum produce both glucosinolates and cardenolides as a defense mechanism against herbivory. Two natural isolates of Erysimum cheiranthoides (wormseed wallflower) differed in their glucosinolate content, cardenolide content, and ...
Mahdieh Mirzaei +5 more
doaj +2 more sources
Insecticidal metabolites from Serratia marcescens associated with the fall armyworm (Spodoptera frugiperda): molecular identification, metabolomic profiling and molecular docking insights [PDF]
Scientific ReportsThe fall armyworm (S. frugiperda) has developed resistance to numerous insecticides and is currently considered one of the most destructive pests threatening global crop production.
Kreema A. El-Lebody +5 more
doaj +2 more sources
Frontiers in Ecology and Evolution, 2023 Milkweed–herbivore systems are characterized by cardenolide chemical defenses and specialized herbivore adaptations such as physiological target site insensitivity.
Paola Rubiano-Buitrago +6 more
doaj +1 more source
Gut-specific cardenolide-resistant sodium pump primed an omnivore to feed on toxic oleander
iScience, 2022 Summary: Apocynaceae plants produce toxic cardenolides to defend against their herbivores. Cardenolides could inhibit the α subunit of Na+⁄K+-ATPase (ATPα), which plays critical roles in biological processes such as muscle contraction, neural function ...
Tianyu Wang, Lina Shi, Ying Zhen
doaj +1 more source