Results 21 to 30 of about 1,686 (179)
Molecules, 2021 Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir +5 more
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Pharmaceuticals, 2021 Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer’s disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs).
Anuradha Thakur +4 more
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Molecules, 2012 In this work, we have evaluated the molluscicidal activity of two cardenolide extracts from <em>Adenium arabicum</em> Balf f. [the benzene (B) and methanol (M) extracts], one cardenolide extract from <em>Calotropis procera</em> ...
Alaa Bayoumi +3 more
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PLoS ONE, 2022 The preference-performance hypothesis explains host specificity in phytophagous insects, positing that host plants chosen by adults confer the greatest larval fitness. However, adults sometimes oviposit on plants supporting low larval success because the
Lewis Greenstein +2 more
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Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
MicrobiologyOpen, 2019 A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs.
Christoph Rieck +7 more
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Host Plant Species Mediates Impact of Neonicotinoid Exposure to Monarch Butterflies
Insects, 2021 Neonicotinoids are the most widely used insecticides in North America. Numerous studies document the negative effects of neonicotinoids on bees, and it remains crucial to demonstrate if neonicotinoids affect other non-target insects, such as butterflies.
Cody Prouty +4 more
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Na,K-ATPase mediated and cardiotonic induced signaling in health and disease
Frontiers in PhysiologyIn the late 1950’s, Na,K-ATPase (NKA) was discovered as the active transport system that establishes and maintains the transmembrane Na+ and K+ gradients necessary for cell survival and function. Almost 70 years later, a novel unexpected function for NKA
Jordan Trant +3 more
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Cytotoxic Cardenolide and Sterols from
Natural Product Communications, 2011 The dichloromethane extract from the leaves of Calotropis gigantea Linn. was strongly cytotoxic against non-small cell lung carcinoma (A549), colon carcinoma (HCT 116) and hepatocellular carcinoma (Hep G2), and non toxic to Chinese hamster ovary (AA8 ...
Sonia D. Jacinto +5 more
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Cardiac glycosides isolated from the Indian-snuff, Maquira sclerophylla Ducke
Memorias do Instituto Oswaldo Cruz, 1991 The hydroalcoholic extract of the powdered bark of the Indian-snuff Maquira sclerophylla Ducke was purified by column chromatography in silica-gel and the major cardenolide isolated from preparative TLC was identified by 1H-NMR, 1 2 C-NMR and IR analyses.
João Ernesto de Carvalho +2 more
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