Results 11 to 20 of about 2,590 (216)
Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae [PDF]
MicrobiologyOpen, 2019 A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs.
Christoph Rieck +7 more
doaj +2 more sources
A New Cardenolide and Other Compounds from
Natural Product Communications, 2017 One new cardenolide, 3- O -β-D-allopyranosylcoroglaucigenin (salsotetragonin) ( 1 ), was isolated from the aerial parts of Salsola tetragona Delile with four known cardenolides ( 2–5 ), two known flavonoids ( 6–7 ), three known phenolic compounds ( 8–10 )
Hamida Ghorab +7 more
doaj +2 more sources
Functional Ecology, Volume 40, Issue 2, Page 501-516, February 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Coevolutionary arms races between plants and insects, in which gains of novel plant defences select for counteradaptations in herbivores, are key drivers of biodiversity.
Broti Biswas +5 more
wiley +2 more sources
Environment and Host Genetics Drive Infection Outcomes in a Butterfly Host, but Do Not Interact With Each Other. [PDF]
Ecol EvolThis study examined how host genetics and larval food plant environment influence parasite infection outcomes in monarch butterflies (Danaus plexippus) infected with the protozoan Ophryocystis elektroscirrha. We tested for genotype × environment interactions on infection status, infection burden, lifespan, and wing size.
Majewska AA, Chlebove G, de Roode JC.
europepmc +2 more sources
Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]
Mol Ecol ResourABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
europepmc +2 more sources
Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]
Small MethodsCardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M +7 more
europepmc +2 more sources
Molecules, 2022 Cardiac glycosides are a large class of secondary metabolites found in plants. In the genus Asclepias, cardenolides in milkweed plants have an established role in plant–herbivore and predator–prey interactions, based on their ability to inhibit the ...
Paola Rubiano-Buitrago +3 more
doaj +1 more source
RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content [PDF]
, 2021 Key message Studying RNAi-mediated DlP5βR1 and DlP5βR2 knockdown shoot culture lines of Digitalis lanata, we here provide direct evidence for the participation of PRISEs (progesterone 5β-reductase/iridoid synthase-like enzymes) in 5β-cardenolide ...
Horn, Elisa +19 more
core +1 more source
Ecology and Evolution, 2021 Sequestration, that is, the accumulation of plant toxins into body tissues for defense, was predicted to incur physiological costs and may require resistance traits different from those of non‐sequestering insects.
Prayan Pokharel +2 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2018 Calotropis gigantea produces specialized secondary metabolites known as cardenolides, which have anticancer and antimalarial properties. Although transcriptomic studies have been conducted in other cardenolide-producing species, no nuclear genome ...
Genevieve M. Hoopes +6 more
doaj +1 more source