Results 11 to 20 of about 2,274 (220)
MicrobiologyOpen, 2019 A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs.
Christoph Rieck +7 more
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Cytotoxic Cardenolide and Sterols from
Natural Product Communications, 2011 The dichloromethane extract from the leaves of Calotropis gigantea Linn. was strongly cytotoxic against non-small cell lung carcinoma (A549), colon carcinoma (HCT 116) and hepatocellular carcinoma (Hep G2), and non toxic to Chinese hamster ovary (AA8 ...
Sonia D. Jacinto +5 more
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A New Cardenolide and Other Compounds from
Natural Product Communications, 2017 One new cardenolide, 3- O -β-D-allopyranosylcoroglaucigenin (salsotetragonin) ( 1 ), was isolated from the aerial parts of Salsola tetragona Delile with four known cardenolides ( 2–5 ), two known flavonoids ( 6–7 ), three known phenolic compounds ( 8–10 )
Hamida Ghorab +7 more
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Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]
Mol Ecol ResourABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
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Cardenolide-Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non-small Cell Lung Cancer Cells. [PDF]
Small MethodsCardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Dorfner M +7 more
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G3: Genes, Genomes, Genetics, 2018 Calotropis gigantea produces specialized secondary metabolites known as cardenolides, which have anticancer and antimalarial properties. Although transcriptomic studies have been conducted in other cardenolide-producing species, no nuclear genome ...
Genevieve M. Hoopes +6 more
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Characterization and Chromatographic Fingerprint Analysis of Traditional Wallflower Oil [PDF]
Research Journal of Pharmacognosy, 2021 Background and objective: Wallflower oil is made from the flowers of Erysimum cheiri (L.) Crantz which is a herb rich in cardenolide compounds. Wallflower oil was traditionally indicated for analgesic, anti-inflammatory, hair tonic, and wound healing ...
Ghazaleh Mosleh +2 more
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Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle. [PDF]
PLoS ONE, 2014 In the past decade, there has been a profound increase in the number of studies revealing that cardenolide glycosides display inhibitory activity on the growth of human cancer cells.
Wohn-Jenn Leu +7 more
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Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito
Molecules, 2015 A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (
Jae-Woo Jung +10 more
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Unraveling the roles of genotype and environment in the expression of plant defense phenotypes
Ecology and Evolution, 2021 Phenotypic variability results from interactions between genotype and environment and is a major driver of ecological and evolutionary interactions. Measuring the relative contributions of genetic variation, the environment, and their interaction to ...
Abigail S. Potts, Mark D. Hunter
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