Results 41 to 50 of about 777,596 (195)

Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect

Journal of Physiological Sciences
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death.
Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu, Hideki Sakai   +4 more
doaj   +1 more source

Development and Validation of an Analytical Procedure for Determining Convallatoxin in Medicinal Products Containing Cardiac Glycosides of Lily of the Valley

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The safe use of lily-of-the-valley medicinal products requires adequately controlling the content of cardiac glycosides. The State Pharmacopoeia of the Russian Federation stipulates that the content of cardiac glycosides in lily-of-the ...
T. A. Golomazova, N. P. Antonova, N. E. Semenova, E. P. Shefer, S. S. Prokhvatilova   +4 more
doaj   +1 more source

Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects

Frontiers in Plant Science, 2018
A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive.
Georg Petschenka, Colleen S. Fei, Juan J. Araya, Susanne Schröder, Barbara N. Timmermann, Anurag A. Agrawal   +5 more
doaj   +1 more source

Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria

, 2016
Phytochemical investigation of the latex of Antiaris toxicaria resulted in the isolation of 15 new [antiarosides J–X (1–15)] and 17 known cardiac glycosides. The effects of the cardiac glycosides on apoptosis and the expression of orphan nuclear receptor
Xiao-Kun Zhang (1701931), Guang-Hui Wang (257862), Shun-Lin Li (1475941), Qian Liu (135614), Meng-Jie Hu (1906198), Jie Liu (15128), Jin-Shan Tang (1426240), Hai-Feng Chen (141242), Xiao-Jiang Hao (693964), Xin-Sheng Yao (371450), Hao Gao (154820)   +10 more
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Thevetia thevetioides Cardenolide and Related Cardiac Glycoside Profile in Mature and Immature Seeds by High-Resolution Thin-Layer Chromatography (HPTLC) and Quadrupole Time of Flight–Tandem Mass Spectrometry (Q-TOF MS/MS) Reveals Insights of the Cardenolide Biosynthetic Pathway

Molecules
Thevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus.
Juan Vázquez-Martínez, Paulina Bravo-Villa, Jorge Molina-Torres   +2 more
doaj   +1 more source

Anticonvulsive potential of cardiac glycosides under conditions of pentilentetrazole-induced seizures in mice: comparative study

Acta Medica Leopoliensia, 2021
Aim. The research provides a comparative analysis of the possible anticonvulsant action of different cardiac glycosides, namely: digoxin, lanatoside C, strophanthin G and corglycone.
V.V. Tsyvunin, S.Yu. Shtrygol', D.V. Shtrygol', D.P. Kavraiskyi   +3 more
doaj   +1 more source

Steroidal Glycosides of Cordyline australis [PDF]

, 2006
The n-butanol extract of aerial parts of Cordyline australis demonstrated antifungal activity. n-Butanol and chloroform extracts of dried or fresh leaves of C. australis afforded a steroidal glycoside, which was identified as 5α-spirost-25(27)-en-3β-ol 3-
Korkashvili, Tamar
core  

Nutraceutical Benefits of Anchomanes difformis Rhizome and Its Effects on Blood Glucose and Hepatorenal Function in Normoglycemic Rats

Food Chemistry International, EarlyView.
Scientific analysis of Anchomanes difformis roots confirms significant nutraceutical potential, containing high levels of carbohydrates, proteins, and essential minerals. Phytochemical screening revealed antioxidants such as phenols and flavonoids, and although the extracts effectively lowered plasma glucose, safety testing showed dose‐dependent risks.
Lawrence Folorunso Dada, Kingsley Omage, Marshall Arebojie Azeke   +2 more
wiley   +1 more source