Cardiac Glycosides in Human Physiology and Disease: Update for Entomologists [PDF]
Insects, 2019 Cardiac glycosides, cardenolides and bufadienolides, are elaborated by several plant or animal species to prevent grazing or predation. Entomologists have characterized several insect species that have evolved the ability to sequester these glycosides in
Rif S. El-Mallakh +2 more
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Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells [PDF]
Cardiology Research and Practice, 2019 Cardiac glycosides are a group of compounds widely known for their action in cardiac tissue, some of which have been found to be endogenously produced (ECG).
Alejandro Ogazon del Toro +6 more
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Cardiac glycosides are broad-spectrum senolytics. [PDF]
Nat Metab, 2019 Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also exacerbate tumorigenesis through the secretion of proinflammatory factors ...
Guerrero A +25 more
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"Cardiac glycosides"-quo vaditis?-past, present, and future? [PDF]
Naunyn Schmiedebergs Arch PharmacolUp to date, digitalis glycosides, also known as “cardiac glycosides”, are inhibitors of the Na+/K+-ATPase. They have a long-standing history as drugs used in patients suffering from heart failure and atrial fibrillation despite their well-known narrow ...
Fender J +5 more
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Cardiotoxicity of Plants in Iran: a Review [PDF]
The Iranian Journal of Veterinary Science and Technology, 2018 In this review an attempt has been made to review the cardiotoxic effects of poisonous plants which are found in Iran. Among various plant species growing in different regions of Iran, a large number of plants contain chemical compounds which are ...
Mohammad R. Aslani
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Cardiac Glycosides and Cardiomyopathy [PDF]
Hypertension, 2006 Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
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The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction. [PDF]
PLoS ONE, 2017 Cardiac glycosides such as digoxin are Na+/K+-ATPase inhibitors that are widely used for the treatment of chronic heart failure and cardiac arrhythmias; however, recent epidemiological studies have suggested a relationship between digoxin treatment and ...
Motoi Kobayashi +9 more
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Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity
Frontiers in Cardiovascular Medicine, 2022 Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, it is poorly understood how cardiomyocyte proliferation is regulated, and no factor identified to promote mammalian cardiomyocyte proliferation has been ...
Ajit Magadum +11 more
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Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. [PDF]
PLoS ONE, 2009 BACKGROUND:Cardiac glycosides are Na(+)/K(+)-pump inhibitors widely used to treat heart failure. They are also highly cytotoxic, and studies have suggested specific anti-tumor activity leading to current clinical trials in cancer patients.
Andrea Perne +10 more
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Identification of key genes involved in secondary metabolite biosynthesis in Digitalis purpurea
PLoS ONE, 2023 The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures.
Fatemeh Amiri +3 more
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