Results 21 to 30 of about 14,654 (172)

CARDIAC GLYCOSIDES IN UP-TO-DATE CLINICAL PRACTICE

Alʹmanah Kliničeskoj Mediciny, 2016
The article reviews the use of cardiac glycosides in patients with chronic heart failure, paroxysmal tachyarrhythmia and chronic atrial fibrillation (rate control).
M. A. Gurevich, A. A. Gavrilin
doaj   +1 more source

Pharmacological aspects of acute treatment glycoside intoxication

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling, E. G. Kruchinin, A. S. Gogolevsky   +2 more
doaj   +1 more source

Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.

PLoS ONE, 2014
Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na+/K+ ATPase (NKA), which raises [Na+]i and attenuates Ca2+ extrusion via the Na+/Ca2+ exchanger (NCX), causing [Ca2+]i elevation.
Qince Li, Steven M Pogwizd, Sumanth D Prabhu, Lufang Zhou   +3 more
doaj   +1 more source

Function of inhibition of RNA virus replication by digoxin and oleandrin [PDF]

Xin yixue, 2023
Objective To evaluate the antiviral ability of cardiac glycosides of digoxin and oleandrin. Methods Human adenocarcinoma alveolar basal epithelial cell line （A549） and African green monkey kidney cell line （vero） were used for subsequent experiment.
Liao Xialin, Liang Wei, Chen Jiawen, Liu Kunpeng
doaj   +1 more source

Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia [PDF]

Veterinary World, 2022
Background and Aim: The utilization of cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves from Bojonegoro Regency has led to the poisoning of livestock due to antinutritional factors ...
Maria Rosaria Odilia, Dhiya Tajhanun Zahra Astika Putri, Antasiswa Windraningtyas Rosetyadewi, Agustina Dwi Wijayanti, Agung Budiyanto, Arvendi Rachma Jadi, Anggi Muhtar Pratama   +6 more
doaj   +1 more source

The role of fluorescence polarization immuno-assay in the diagnosis of plant-induced cardiac glycoside poisoning livestock in South Africa

Onderstepoort Journal of Veterinary Research, 2005
Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz, T.S. Kellerman, H. Van den Berg   +2 more
doaj   +1 more source

Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect

Journal of Physiological Sciences
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death.
Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu, Hideki Sakai   +4 more
doaj   +1 more source

Development and Validation of an Analytical Procedure for Determining Convallatoxin in Medicinal Products Containing Cardiac Glycosides of Lily of the Valley

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The safe use of lily-of-the-valley medicinal products requires adequately controlling the content of cardiac glycosides. The State Pharmacopoeia of the Russian Federation stipulates that the content of cardiac glycosides in lily-of-the ...
T. A. Golomazova, N. P. Antonova, N. E. Semenova, E. P. Shefer, S. S. Prokhvatilova   +4 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects

Frontiers in Plant Science, 2018
A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive.
Georg Petschenka, Colleen S. Fei, Juan J. Araya, Susanne Schröder, Barbara N. Timmermann, Anurag A. Agrawal   +5 more
doaj   +1 more source