Results 21 to 30 of about 17,469 (205)

Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity

Frontiers in Cardiovascular Medicine, 2022
Promoting cardiomyocyte proliferation is a promising strategy to regenerate the heart. Yet, so far, it is poorly understood how cardiomyocyte proliferation is regulated, and no factor identified to promote mammalian cardiomyocyte proliferation has been ...
Ajit Magadum, Ajit Magadum, Ajit Magadum, Harsha V. Renikunta, Harsha V. Renikunta, Neha Singh, Conchi Estaras, Raj Kishore, Raj Kishore, Felix B. Engel, Felix B. Engel, Felix B. Engel   +11 more
doaj   +1 more source

Identification of key genes involved in secondary metabolite biosynthesis in Digitalis purpurea

PLoS ONE, 2023
The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures.
Fatemeh Amiri, Ali Moghadam, Ahmad Tahmasebi, Ali Niazi   +3 more
doaj   +2 more sources

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status

Cell Communication and Signaling, 2023
Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by an accumulation of immature leukemic myeloblasts initiating from leukemic stem cells (LSCs)—the subpopulation that is also considered the root cause of ...
Jirarat Poohadsuan, George A. O’Doherty, Weerapat Owattanapanich, Smith Kungwankiattichai, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong   +6 more
doaj   +1 more source

Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]

, 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía, Maldonado Navas, Dolores, García Domínguez, Irene, Calderón Montaño, José Manuel, López Lázaro, Miguel, Orta Vázquez, Manuel Luis   +5 more
core   +1 more source

Pharmacological aspects of acute treatment glycoside intoxication

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling, E. G. Kruchinin, A. S. Gogolevsky   +2 more
doaj   +1 more source

Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.

PLoS ONE, 2014
Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na+/K+ ATPase (NKA), which raises [Na+]i and attenuates Ca2+ extrusion via the Na+/Ca2+ exchanger (NCX), causing [Ca2+]i elevation.
Qince Li, Steven M Pogwizd, Sumanth D Prabhu, Lufang Zhou   +3 more
doaj   +1 more source

Function of inhibition of RNA virus replication by digoxin and oleandrin [PDF]

Xin yixue, 2023
Objective To evaluate the antiviral ability of cardiac glycosides of digoxin and oleandrin. Methods Human adenocarcinoma alveolar basal epithelial cell line （A549） and African green monkey kidney cell line （vero） were used for subsequent experiment.
Liao Xialin, Liang Wei, Chen Jiawen, Liu Kunpeng
doaj   +1 more source

Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia [PDF]

Veterinary World, 2022
Background and Aim: The utilization of cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves from Bojonegoro Regency has led to the poisoning of livestock due to antinutritional factors ...
Maria Rosaria Odilia, Dhiya Tajhanun Zahra Astika Putri, Antasiswa Windraningtyas Rosetyadewi, Agustina Dwi Wijayanti, Agung Budiyanto, Arvendi Rachma Jadi, Anggi Muhtar Pratama   +6 more
doaj   +1 more source

The role of fluorescence polarization immuno-assay in the diagnosis of plant-induced cardiac glycoside poisoning livestock in South Africa

Onderstepoort Journal of Veterinary Research, 2005
Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz, T.S. Kellerman, H. Van den Berg   +2 more
doaj   +1 more source

Screening for cardiac glycosides in Schizobasis intricata

, 1995
Traditional herbalists in Natal use Schizobasis intricata (Bak.) Bak, as a substitute for Bowiea volubilis Harv. ex Hook. This may be due to morphological confusion of the two species or they may elicit a similar biological response.
Jäger, Anna K., van Staden, J.
core   +1 more source