Results 31 to 40 of about 777,596 (195)

Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]

, 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía, Maldonado Navas, Dolores, García Domínguez, Irene, Calderón Montaño, José Manuel, López Lázaro, Miguel, Orta Vázquez, Manuel Luis   +5 more
core   +1 more source

IDENTIFICATION AND EXTRACTION PROCESS OF CARDIAC GLYCOSIDES FROM FOXGLOVE PLANTS [PDF]

Foxglove (Digitalis spp.) is a plant known for its cardiac glycoside content, which has been used in medicine for centuries. Cardiac glycosides, such as digoxin and digitoxin, are the main components that have a therapeutic effect on the cardiovascular ...
Juarfianti, Juarfianti, Elviona, Rema, Kusuma, Ika Meruya, Febrianti, Susi, Farhan, Fathi, Salfa, Sabrina Audry   +5 more
core   +3 more sources

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status

Cell Communication and Signaling, 2023
Background Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by an accumulation of immature leukemic myeloblasts initiating from leukemic stem cells (LSCs)—the subpopulation that is also considered the root cause of ...
Jirarat Poohadsuan, George A. O’Doherty, Weerapat Owattanapanich, Smith Kungwankiattichai, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong   +6 more
doaj   +1 more source

Pharmacological aspects of acute treatment glycoside intoxication

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling, E. G. Kruchinin, A. S. Gogolevsky   +2 more
doaj   +1 more source

Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.

PLoS ONE, 2014
Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na+/K+ ATPase (NKA), which raises [Na+]i and attenuates Ca2+ extrusion via the Na+/Ca2+ exchanger (NCX), causing [Ca2+]i elevation.
Qince Li, Steven M Pogwizd, Sumanth D Prabhu, Lufang Zhou   +3 more
doaj   +1 more source

Function of inhibition of RNA virus replication by digoxin and oleandrin [PDF]

Xin yixue, 2023
Objective To evaluate the antiviral ability of cardiac glycosides of digoxin and oleandrin. Methods Human adenocarcinoma alveolar basal epithelial cell line （A549） and African green monkey kidney cell line （vero） were used for subsequent experiment.
Liao Xialin, Liang Wei, Chen Jiawen, Liu Kunpeng
doaj   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +2 more sources

Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia [PDF]

Veterinary World, 2022
Background and Aim: The utilization of cassava leaves and peels, ceara rubber leaves, sweet potato leaves, Chinese Albizia leaves, and lophatheri leaves from Bojonegoro Regency has led to the poisoning of livestock due to antinutritional factors ...
Maria Rosaria Odilia, Dhiya Tajhanun Zahra Astika Putri, Antasiswa Windraningtyas Rosetyadewi, Agustina Dwi Wijayanti, Agung Budiyanto, Arvendi Rachma Jadi, Anggi Muhtar Pratama   +6 more
doaj   +1 more source

The role of fluorescence polarization immuno-assay in the diagnosis of plant-induced cardiac glycoside poisoning livestock in South Africa

Onderstepoort Journal of Veterinary Research, 2005
Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz, T.S. Kellerman, H. Van den Berg   +2 more
doaj   +1 more source

A dual effect of cardiac glycosides on Ca current in single cells of frog heart

, 1986
International audienceThe effects of cardiac glycosides (1 µM ouabain, 50 µM dihydroouabain, 1 #H strophanthidin) on Ca current (ICa) were investigated on Cs-loaded single frog ventrlcular cells using the whole-cell patch-clamp technique.
Vassort, Guy, Brocas-Randolph, Mireiile, Fischmeister, Rodolphe, Lechêne, P, Argibay, Jorge   +4 more
core   +1 more source