Results 61 to 70 of about 31,811 (218)

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival

open access: yesMolecular Cancer, 2011
Background Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months.
Velculescu Victor E   +3 more
doaj   +1 more source

Plant Toxins: Poison or Therapeutic?

open access: yesCHIMIA, 2020
Many plants that are classed as poisonous also have therapeutic uses, and this is illustrated using members of the Drimia and Digitalis genera which are sources of cardiac glycosides.
Catherine E. Housecroft
doaj   +1 more source

A suicide attempt by ingestion of oleander leaves and treatment with digoxin-specific Fab antibody fragments

open access: yesArhiv za Higijenu Rada i Toksikologiju, 2023
Natural cardiac glycosides have positive inotropic heart effects but at high, toxic doses they can cause life-threatening cardiac arrhythmias. Here we present the first Croatian case of a 16-year-old girl who attempted suicide by eating dried oleander ...
Kovačević Tanja   +6 more
doaj   +1 more source

Evaluation of HSYA and Carthamin Accumulation in Safflower (Carthamus tinctorius L.) Induced by Chemical Mutagens (EMS and SA) in M1 and M2 Generations

open access: yesPlant Breeding, EarlyView.
ABSTRACT Historically cultivated for medicinal and dyeing purposes, safflower (Carthamus tinctorius L.) saw a shift towards widespread oilseed production after the 1920s due to the growing importance of oils. However, there is a renewed interest in its medicinal and dyeing properties today.
Tansu Uskutoglu   +2 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican   +4 more
wiley   +1 more source

Gas Chromatography‐Mass Spectrometry‐Based Phytochemical Profiling and Bioactivity‐Guided Fractionation of Psidium guineense Stem Extracts: In Vitro and In Silico Insights Into Antioxidant, Antidiabetic and Antibacterial Potentials

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Psidium guineense (Myrtaceae) is traditionally used for various medicinal purposes, although its stem remains underexplored. This study provides the first integrated phytochemical, pharmacological and computational evaluation of the stem extracts to elucidate their antioxidant, antidiabetic and antibacterial potential.
Md. Jahid Hossain   +3 more
wiley   +1 more source

The Environmental Fluctuations of some Bioactive Nutraceutical Compounds in Zilla spinosa Inhabiting Arid Habitats

open access: yesNotulae Scientia Biologicae, 2017
Zilla spinosa is one of the dominated woody perennial shrubs widespread in the Egyptian Red sea coastal desert, belonging to family Brassicacea. Z. spinosa is used as a folk medicine and for heating by local people. Z.
Hemmat Ibrahim KHATTAB   +3 more
doaj   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

open access: yesIsrael Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff   +2 more
wiley   +1 more source

Localization of Na pumps in the tracheal epithelium of the dog. [PDF]

open access: yes, 1979
Binding of [3H]ouabain by the dog's tracheal epithelium shows a nonspecific component depending linearly on ouabain concentration, and a specific saturable component with a Km of 10(-7) M.
Basbaum, CB, Widdicombe, JH, Yee, JY
core  

Possible Deslanoside‐Induced Left Posterior Fascicular Ventricular Tachycardia: A Case Report

open access: yesAnnals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
A 73‐year‐old man with paroxysmal AF and no structural heart disease who developed left posterior fascicular ventricular tachycardia (LPFVT) shortly after intravenous Deslanoside administration for rate control. Highlights: cardiac glycosides, though effective for rate control, may occasionally precipitate Purkinje‐related ventricular tachycardia ...
Zhang Wenjun, Chen Yao
wiley   +1 more source

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