Results 71 to 80 of about 14,654 (172)

Standardizing Medicinal Products with Convallaria majalis Cardiac Glycosides: The Prospect of Phasing out Biological Method

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The approved Russian regulations and guidelines on identification of medicinal products containing Convallaria majalis cardiac glycosides use group identification tests and thin-layer chromatography; spectrophotometry and bioassay are ...
T. A. Golomazova, N. P. Antonova, N. E. Semenova, E. P. Shefer, S. S. Prokhvatilova, V. L. Bagirova   +5 more
doaj   +1 more source

Topics on the Na+/Ca2+ Exchanger: Role of Vascular NCX1 in Salt-Dependent Hypertension

Journal of Pharmacological Sciences, 2006
Excess salt intake is a major risk factor for hypertension. However, the molecular mechanisms underlying salt-dependent hypertension remain obscure. Our recent studies using selective Na+/Ca2+ exchange inhibitors and genetically engineered mice provide ...
Takahiro Iwamoto, Satomi Kita
doaj   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.
ABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Severe symptomatic bradycardia after a dinner of spicy oleander soup

Emergency Care Journal, 2016
Cardiac glycosides similar to digoxin are produced by different plants in nature. Nerium oleander, commonly grown as an ornamental shrub, can be found worldwide in temperate countries. Intentional or accidental ingestion of any part of the plant can lead
Andrea Tampieri, Fabrizio Mucci, Valeria Palmonari, Eugenio Giovannini, Tiziano Lenzi, Patrizia Cenni   +5 more
doaj   +1 more source

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Phytotherapy Research, Volume 40, Issue 8, Page 5299-5315, August 2026.
Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi, Panagiota‐Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios‐Leandros Skaltsounis, Ioanna Andreadou   +15 more
wiley   +1 more source

Dietary nutgrass (Cyperus rotundus) extract–loaded chitosan nanoparticles: Enhance growth performance, boost immune responses, improve antioxidant capacity, and physiological performance in white leg shrimp (Litopenaeus vannamei)

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract Aquaculture has increasingly turned toward plant extracts' usage as functional additives, owing to their rich content of bioactive compounds that enhance growth performance, boost immune responses, and improve antioxidant capacity in cultured species.
Nader N. Hassona, Nauman Khan, Maryam Alenize, Ahmed Tayel, Salma Elhussein, Jia Longwu, Huici Yang, Yun Li, Nusrat Liaqat, Xilin Dai   +9 more
wiley   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

ACUTE INTAKE OF A LARGE DOSE OF CARDIAC GLYCOSIDES BY A YOUNG MALE

Проблеми екології та медицини, 2017
One of the most toxic drugs is a group of cardiac glycosides. Having a very narrow spectrum of therapeutic action, cardiac glycosides are able to cause serious intoxication with complications including arrhythmias and conduction disorder, which often ...
L. Savchenko, I. Mormol, P. Husar, N. Reva, O. Borzykh, I. Kaydashev   +5 more
doaj  

Antidote use for cardiac arrest or hemodynamic instability due to cardiac glycoside poisoning: A narrative review

Resuscitation Plus
Introduction: Cardiac glycosides comprise medications such as digoxin and digitoxin, plants, and even certain toad venoms. Intoxication with cardiac glycosides can lead to hemodynamic instability and cardiac arrest.
Jessie Beaulieu, Maude St-Onge
doaj   +1 more source

Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A

Discover Pharmaceutical Sciences
Several cardiac glycosides, including digoxin, digitoxin, and proscillaridin A, have been originally identified as cardiomyocyte modulators and are currently being investigated for their anticancer properties.
Shreya Somani, Lekhya Menta, Feng Wang-Johanning, Gary Johanning, Seoyeon Hong, Edward Njoo   +5 more
doaj   +1 more source