Results 61 to 70 of about 4,113 (206)
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Yanfang Zhang +10 more
wiley +1 more source
, 2002 Cell suspension cultures of Capsicum frutescens accumulated digoxin, purpureaglycoside A and other unknown derivatives when digitoxin, a cardiac glycoside, was used as a precursor.
Ramachandra Rao, S. +2 more
core +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi +12 more
wiley +1 more source
Case Studies in Thermal EngineeringThis paper investigates the solubility behavior of digitoxin in supercritical carbon dioxide (CO2) through a comprehensive analysis employing ensemble learning techniques and various regression models.
Meixiuli Li +4 more
doaj +1 more source
International Journal of Secondary Metabolite, 2017 The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin +2 more
doaj +1 more source
Journal of Separation Science, Volume 49, Issue 2, February 2026.ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage +8 more
wiley +1 more source
Studies on the Relationship Between the Cumulative Effect of Digitalis and Distribution of Digitoxin in Tissues of Cat [PDF]
In order to determine the mechanism of cumulative effect of digitalis, the author investigated the distribution of digitoxin in miscellaneous tissue of the cat at 1 and 48 hr after a single intravenous injection of 3H-digitoxin （20% of the standard ...
塚田, 英樹
core +1 more source
Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death
Molecules, 2016 Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng +3 more
doaj +1 more source
Small Methods, Volume 10, Issue 3, 9 February 2026.Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner +7 more
wiley +1 more source