Results 51 to 60 of about 4,113 (206)
Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng +6 more
wiley +1 more source
Digitoxin as a novel synergistic partner of cisplatin in triple-negative breast cancer (TNBC) cells
Tumor BiologyBackground Triple-negative breast cancer (TNBC) remains clinically challenging due to its aggressive nature, high recurrence rate, and lack of targeted therapies.
Sara A. Al-Shun +2 more
doaj +1 more source
Molecules, 2016 Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang +11 more
doaj +1 more source
Drugs - Real World Outcomes, 2023 Background Cardiac glycosides such as digoxin, digitoxin and ouabain are still used around the world to treat patients with chronic heart failure with reduced ejection fraction (HFrEF) and/or atrial fibrillation (AF).
Amanda L. Banaag +2 more
doaj +1 more source
Progress in Natural Products Target Discovery Technology
MedComm, Volume 7, Issue 6, June 2026.Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan +7 more
wiley +1 more source
Intracellular Distribution of Digitoxin.
Experimental Biology and Medicine, 1953 SummaryThe hearts and livers of animals given intravenous digi toxin were homogenized and separated by centrifugation into nuclear, mitochondrial and homogeneous supernatant fractions. More than 85% of the digi toxin was found in the supernatant fractions of both heart and liver, while the mitochondria of the organs contained 3 and 0.1%.
S, ST. GEORGE, M, FRIEDMAN, T, ISHIDA
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili +16 more
wiley +1 more source
Digitoxin improves cardiovascular autonomic control in rats with heart failure [PDF]
, 2015 The effects of chronic treatment with digitoxin on arterial baroreceptor sensitivity for heart rate (HR) and renal sympathetic nerve activity (rSNA) control, cardiopulmonary reflex, and autonomic HR control in an animal model of heart failure were ...
Antonio, Ednei Luiz +5 more
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Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source
Studies on the Accumulation of Digitoxin and the Cumulative Effect of Digitalis. [PDF]
This experiment was planned to determine whether the so-called “cumulative effect of digitoxin”occurs as a result of the true accumulation of digitoxin or is due to the accumulation of digitoxin induced changes.
泉, 尭
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