Results 51 to 60 of about 3,653 (213)

Na+/K+‑ATPase subunit α3 expression is associated with the efficacy of digitoxin treatment in pancreatic cancer cells

, 2022
The alpha subunits (ATP1A1-3) of Na(+)/K(+)-ATPase binds digitoxin with varying affinity. The expression levels of these subunits dictate the anticancer effects of digitoxin.
Lindholm, Heléne,, Ejeskär, Katarina, Szekeres, Ferenc,, Lindholm, Heléne, Ejeskär, Katarina,, Szekeres, Ferenc   +5 more
core   +1 more source

Short term protective effect of digitoxin in sepsis-induced acute lung injury [PDF]

, 2022
Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in ...
Özkul, Bahattin, Bora, Ejder Saylav, Sever, İbrahim Halil, Erdoğan, Mümin Alper, Erbaş, Oytun, Söğüt, İbrahim, Hürdağ, Canan   +6 more
core   +1 more source

Microscale Affinity Chromatography for Biointeraction Analysis: Strategies, Principles and Applications

Journal of Separation Science, Volume 49, Issue 2, February 2026.
ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage, Nigar Sultana Pinky, B. K. Sajeeb, Md Masudur Rahman, Harshana Olupathage, Samiul Alim, Isaac Kyei, Zoe Zingler, Sanduni Heenkenda   +8 more
wiley   +1 more source

Intracellular Distribution of Digitoxin.

Experimental Biology and Medicine, 1953
SummaryThe hearts and livers of animals given intravenous digi toxin were homogenized and separated by centrifugation into nuclear, mitochondrial and homogeneous supernatant fractions. More than 85% of the digi toxin was found in the supernatant fractions of both heart and liver, while the mitochondria of the organs contained 3 and 0.1%.
S, ST. GEORGE, M, FRIEDMAN, T, ISHIDA
openaire   +2 more sources

Employment of artificial intelligence approach for optimizing the solubility of drug in the supercritical CO2 system

Case Studies in Thermal Engineering
This paper investigates the solubility behavior of digitoxin in supercritical carbon dioxide (CO2) through a comprehensive analysis employing ensemble learning techniques and various regression models.
Meixiuli Li, Wenyan Jiang, Shuang Zhao, Kai Huang, Dongxiu Liu   +4 more
doaj   +1 more source

Investigation of Relationship Between Chemical Stress Factors and Certain Metabolites Including Cardenolides in Callus Cultures of Endemic Turkish Digitalis L. Species

International Journal of Secondary Metabolite, 2017
The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin, Sandeep Kumar Verma, Ekrem Gurel   +2 more
doaj   +1 more source

Evolutionary constraints in host shifts: Limited adaptation of Plutella xylostella to cardenolide‐defended Erysimum cheiranthoides

Functional Ecology, Volume 40, Issue 2, Page 501-516, February 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Coevolutionary arms races between plants and insects, in which gains of novel plant defences select for counteradaptations in herbivores, are key drivers of biodiversity.
Broti Biswas, Erik van Bergen, Teresa Vaello, Laura J. Dällenbach, Christopher W. Wheat, Tobias Züst   +5 more
wiley   +1 more source

Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death

Molecules, 2016
Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng, Wa Seng Leong, Liang Liu, Wai-In Chan   +3 more
doaj   +1 more source

Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post‐transplant mortality

ESC Heart Failure, 2020
Aims Amiodarone and digitalis are frequently used drugs in patients with heart failure. Both have separately been linked to reduced post‐transplant survival, but their combined impact on mortality after HTX remains uncertain.
Rasmus Rivinius, Matthias Helmschrott, Ann‐Kathrin Rahm, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Andreas O. Doesch, Philipp Ehlermann, Hugo A. Katus, Edgar Zitron   +9 more
doaj   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source