Results 71 to 80 of about 3,653 (213)

Drug–Drug Interaction Signals for Apixaban‐Associated Haemorrhage in Atrial Fibrillation and Thromboembolic Disorders: A Disproportionality Analysis of the FAERS Database

Journal of Interventional Cardiology, Volume 2026, Issue 1, 2026.
Background Apixaban is commonly used in anticoagulation therapy. Its safety profile is associated with polypharmacy and potential drug–drug interactions (DDIs). Current understanding often focuses on canonical metabolic pathways, while other biological factors of haemorrhagic risk remain not fully described.
Zhuang Chen, Zhi Li, Yuan Lu, Harleen Khatra   +3 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial

, 2023
BackgroundThe present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial.Methods and ...
Hülsmann, Martin, Großhennig, Anika, Heiko von der Leyen, Bauersachs, Johann, Böhm, Michael, Stefan Störk, Udo Bavendiek, Koch, Armin, Maier, Lars, Sebastian Philipp, Zdravkovic, Marja, Andreas Rieth, Zimmermann, Silke, Störk, Stefan, Anika Großhennig, Michael Böhm, Philipp, Sebastian, Xiaofei Liu, Johann Bauersachs, Bavendiek, Udo, Winkler, Sebastian, Münzel, Thomas, Armin Koch, Westenfeld, Ralf, Maier, Lars S., Marja Zdravkovic, Hambrecht, Rainer, Westermann, Dirk, Thomas Münzel, Lichtinghagen, Ralf, Rieth, Andreas, Veltmann, Christian, Ralf Westenfeld, Johannes Schwab, Liu, Xiaofei, Dirk Westermann, Martin Hülsmann, Silke Zimmermann, Rainer Hambrecht, Lars Maier, Thomas Gaspar, Berliner, Dominik, Gaspar, Thomas, Sebastian Winkler, Christian Veltmann, Ralf Lichtinghagen, Dominik Berliner, Leyen, Heiko von der, von der Leyen, Heiko, Schwab, Johannes   +49 more
core   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +1 more source

The Renaissance of Digitoxin Is Overdue [PDF]

Deutsches Ärzteblatt international, 2016
A 12-page review article on heart failure is very commendable (1). However, it is a source of irritation that in such a comprehensive article, a total of six lines is all that is given to the positive inotropic digitalis glycosides. A distinction between digoxin and digitoxin was not provided. Positive experiences have been reported for a long time for
openaire   +2 more sources

Medication adherence in patients with acutely decompensated heart failure: A cross‐sectional study in the emergency department (ADHF‐ED)

European Journal of Heart Failure, Volume 27, Issue 12, Page 2763-2772, December 2025.
The ADHF‐ED trial. ADHF, acutely decompensated heart failure; CHF, chronic heart failure; ED, emergency department; EF, ejection fraction; MRA, mineralocorticoid receptor antagonist; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide. Created with the support of AI (ChatGPT).
Michael Kunz, Juel Maalouli Schaar, Katharina R. Welker, Lucas Lauder, Felix Götzinger, Ingrid Kindermann, Martin Schulz, Michael Böhm, Markus R. Meyer, Felix Mahfoud   +9 more
wiley   +1 more source

Effects of digitoxin on cell migration in ovarian cancer inflammatory microenvironment

, 2018
Clinical and experimental evidence supports a role for cardiac glycosides (CGs) as potential novel anticancer drugs. However, there are no studies reporting the effect of CGs on the inflammatory tumor microenvironment (TME), which plays a central role in
Bolego, Chiara, Trevisi, Lucia, Cignarella, Andrea, Lucia Trevisi, Trenti, Annalisa, Chiara Bolego, Tedesco, Serena, Serena Tedesco, Boscaro, Carlotta, Carlotta Boscaro, Annalisa Trenti, Andrea Cignarella   +11 more
core   +1 more source

Digitoxin Affects Metabolism, ROS Production and Proliferation in Pancreatic Cancer Cells Differently Depending on the Cell Phenotype

, 2022
Digitoxin has repeatedly shown to have negative effects on cancer cell viability; however, the actual mechanism is still unknown. In this study, we investigated the effects of digitoxin (1-100 nM) in four pancreatic cancer cell lines, BxPC-3, CFPAC-1 ...
Lindholm, Heléne,, Ejeskär, Katarina, Szekeres, Ferenc,, Lindholm, Heléne, Katarina Ejeskär, Ejeskär, Katarina,, Szekeres, Ferenc, Heléne Lindholm, Ferenc Szekeres   +8 more
core   +1 more source

The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner [PDF]

, 2020
Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as \textquotedblpositive adhesiotropy\textquotedbl, was demonstrated to be a function of sympathetic ...
Olivares-Florez, Silvana, Schlipp, Angela, Feinendegen, Manouk, Trenz, Sebastian, Egu, Desalegn Tadesse, Waschke, Jens, Schinner, Camilla, Flaswinkel, Heinrich, Kempf, Ellen, Yeruva, Sunil   +9 more
core   +1 more source