Results 71 to 80 of about 6,490 (199)

Evaluation of chromosome abberations induced by digoxin in Chinese hamster ovary cells [PDF]

, 2013
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells.
Saadat, Iraj, Saadat, Mostafa, Sedigh-Ardekani, Mozhgan   +2 more
core  

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Host plants and experimental warming impact fitness and infection outcomes in a migratory butterfly

Ecological Entomology, Volume 50, Issue 6, Page 1159-1171, December 2025.
Host plant species interacted with temperature treatment to shape monarch survival and infection probabilities. Temperature modified the expected role of tropical milkweed, which did not confer OE resistance to monarchs under elevated temperatures.
Isabella G. Ragonese, Christopher Brandon, Joselyne Chavez, Jacobus C. de Roode, Richard J. Hall, Sonia Altizer   +5 more
wiley   +1 more source

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

Exploring the Potential of Tsuruazuki Bean as a Functional Food to Curb Obesity Using Human Amniotic Epithelial Cells and 3T3‐L1 Preadipocytes

Food Frontiers, Volume 6, Issue 5, Page 2359-2375, September 2025.
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid, Farhana Ferdousi, Kazunori Sasaki, Kyoko Toda, Shinya Takahashi, Mari Maeda‐Yamamoto, Hiroko Isoda   +6 more
wiley   +1 more source

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +1 more source

Digitoxin Antagonism by Visnadin

Journal of Pharmaceutical Sciences, 1962
Visnadin, a lactone derived from bishop's weed, has been found to have marked antidotal properties in animals poisoned with digitoxin. It increases survival on acute and chronic administration of the glycoside, prevents the appearance of bradycardia, and reverses cardiac arrhythmias.
Varonos, D.D., Voukydes, P.C., Nikitopoulou, G.C.   +2 more
openaire   +3 more sources

Effects of soil nutrients on the sequestration of plant defence chemicals by the specialist insect herbivore, Danaus plexippus [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110863/1/een12168 ...
Agrawal, Anderson, Awmack, Bernays, Bobbink, Boersma, Bowers, Bowers, Bowers, Brower, Brower, Bukovinszky, Burghardt, Camara, Cohen, Cohen, Dobler, Docherty, Elser, Erickson, Fenn, Fordyce, Frick, Galloway, Hartmann, Hartmann, Holzinger, Jamieson, Kearsley, Keating, Keinänen, Lefevre, Lynch, Malcolm, Malcolm, Mattson, Nishida, Opitz, Prudic, Rasmann, Reichstein, Roode, Sternberg, Tao, Tao, Throop, Vaughan, Vitousek, Vitousek, Zalucki, Zehnder, Zehnder   +51 more
core   +1 more source

A multicentre registry of hospitalized patients with acute and chronic heart failure: Study design of the H2‐registry

ESC Heart Failure, Volume 12, Issue 4, Page 3114-3133, August 2025.
The H2‐Registry: overview, first results and outlook. Abstract Aims Heart failure (HF) is a highly prevalent condition affecting 1–3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high.
Johannes Leiner, Sebastian König, Anne Nitsche, Sven Hohenstein, Jana Nagel, Melchior Seyfarth, Henning Baberg, Alexander Lauten, Hans Neuser, Alexander Staudt, Jürgen Tebbenjohanns, René Andrié, Michael Niehaus, Markus W. Ferrari, Ralf Kuhlen, Andreas Bollmann   +15 more
wiley   +1 more source

Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality

Therapeutics and Clinical Risk Management, 2017
Rasmus Rivinius,1 Matthias Helmschrott,1 Arjang Ruhparwar,2 Ann-Kathrin Rahm,1,3 Fabrice F Darche,1 Dierk Thomas,1 Tom Bruckner,4 Philipp Ehlermann,1 Hugo A Katus,1 Andreas O Doesch1,5 1Department of Cardiology, Angiology and Pneumology, Heidelberg ...
Rivinius R, Helmschrott M, Ruhparwar A, Rahm AK, Darche FF, Thomas D, Bruckner T, Ehlermann P, Katus HA, Doesch AO   +9 more
doaj