Results 41 to 50 of about 3,061 (175)
Molecules, 2016 Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang +11 more
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Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Yanfang Zhang +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi +12 more
wiley +1 more source
Intracellular Distribution of Digitoxin.
Experimental Biology and Medicine, 1953 SummaryThe hearts and livers of animals given intravenous digi toxin were homogenized and separated by centrifugation into nuclear, mitochondrial and homogeneous supernatant fractions. More than 85% of the digi toxin was found in the supernatant fractions of both heart and liver, while the mitochondria of the organs contained 3 and 0.1%.
S, ST. GEORGE, M, FRIEDMAN, T, ISHIDA
openaire +2 more sources
Journal of Separation Science, Volume 49, Issue 2, February 2026.ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage +8 more
wiley +1 more source
Case Studies in Thermal EngineeringThis paper investigates the solubility behavior of digitoxin in supercritical carbon dioxide (CO2) through a comprehensive analysis employing ensemble learning techniques and various regression models.
Meixiuli Li +4 more
doaj +1 more source
International Journal of Secondary Metabolite, 2017 The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin +2 more
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Functional Ecology, Volume 40, Issue 2, Page 501-516, February 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Coevolutionary arms races between plants and insects, in which gains of novel plant defences select for counteradaptations in herbivores, are key drivers of biodiversity.
Broti Biswas +5 more
wiley +1 more source
Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death
Molecules, 2016 Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng +3 more
doaj +1 more source