Results 21 to 30 of about 4,113 (206)
A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa [PDF]
iScienceSummary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield +2 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2023 Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali +3 more
doaj +1 more source
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses
Molecules, 2021 Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition.
Jan Škubník +3 more
doaj +1 more source
Revisiting Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction Trial: Lessons on Statistical Power [PDF]
Heart ViewsAlaa Rahhal, Ashfaq Patel
doaj +2 more sources
Quo vadis Cardiac Glycoside Research?
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
doaj +1 more source
INCREASING PRODUCTIVITY OF DIGOXIN CONTENT IN DIGITALIS LANATA EHRH "IN VITRO" [PDF]
Journal of Plant Production, 2009 Axillary buds Cultures of Digitalis lanata Ehrh were established from seedling, obtained under aseptic conditions. Shoot tip and single node explants were cultured on MS basal solid medium with various of BA concentrations.
M. H. Bekhit
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Digitoxin and its analogs as novel cancer therapeutics
Experimental Hematology & Oncology, 2012 A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A +4 more
doaj +1 more source
The in vivo effect of digitoxin on rat heart phosphatides*
Journal of Lipid Research, 1961 Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin.
G.V. Marinetti, K. Temple, Elmer Stotz
doaj +1 more source
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Molecules, 2021 Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček +3 more
doaj +1 more source
Short term protective effect of digitoxin in sepsis-induced acute lung injury [PDF]
, 2022 Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in ...
Özkul, Bahattin +6 more
core +1 more source