Results 21 to 30 of about 3,653 (213)

Na⁺/K⁺-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation

Molecules, 2021
Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček, Vojtěch Spiwok, Eva Kmoníčková, Silvie Rimpelová   +3 more
doaj   +1 more source

Anti-Hsv Activity of Digitoxin and Its Possible Mechanisms

, 2009
Herpes simplex virus type I (HSV-1) can establish latent infection in the nervous system and usually leads to life- threatening diseases in immunocompromised individuals upon reactivation. Treatment with conventional nucleoside analogue such as acyclovir
蘇峻霆;徐祖安;謝興邦;陳廷祺;高全良;李君男;張淑媛, SU, CHUN-TING;HSU, JOHN TSU-AN;HSIEH, HSING-PANG;CHEN, TING-CHI;KAO, CHUAN-LIANG;LEE, CHUN-NAN;CHANG, SUI-YUAN   +1 more
core   +2 more sources

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

Integrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang   +5 more
doaj   +1 more source

DIGITOXIN [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +2 more sources

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard   +18 more
doaj   +1 more source

Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors

Digital Chinese Medicine, 2023
Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
doaj   +1 more source

In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations

Molecules, 2022
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed, Rafaela S. Ferreira, José Rogério A. Silva   +2 more
doaj   +1 more source

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

Scientific Reports, 2021
To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I. Walton, Tony T. Wang, Harvey B. Pollard   +8 more
doaj   +1 more source

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Respiratory Research, 2019
Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs.
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard   +9 more
doaj   +1 more source

Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up. [PDF]

Clin Pharmacol Ther
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Tremmel R, Schreeck F, Jaeger S, Schricker S, Schaeffeler E, Igel S, Steinberger D, Pagitz M, Latus J, Ketteler M, Bühl K, Dahlke MH, Kopp HG, Schwab M.   +13 more
europepmc   +2 more sources