Results 31 to 40 of about 4,113 (206)

Anti-Hsv Activity of Digitoxin and Its Possible Mechanisms

, 2009
Herpes simplex virus type I (HSV-1) can establish latent infection in the nervous system and usually leads to life- threatening diseases in immunocompromised individuals upon reactivation. Treatment with conventional nucleoside analogue such as acyclovir
蘇峻霆;徐祖安;謝興邦;陳廷祺;高全良;李君男;張淑媛, SU, CHUN-TING;HSU, JOHN TSU-AN;HSIEH, HSING-PANG;CHEN, TING-CHI;KAO, CHUAN-LIANG;LEE, CHUN-NAN;CHANG, SUI-YUAN   +1 more
core   +2 more sources

DIGITOXIN [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +2 more sources

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard   +18 more
doaj   +1 more source

Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors

Digital Chinese Medicine, 2023
Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
doaj   +1 more source

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

Integrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang   +5 more
doaj   +1 more source

In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations

Molecules, 2022
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed, Rafaela S. Ferreira, José Rogério A. Silva   +2 more
doaj   +1 more source

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

Scientific Reports, 2021
To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I. Walton, Tony T. Wang, Harvey B. Pollard   +8 more
doaj   +1 more source

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Respiratory Research, 2019
Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs.
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard   +9 more
doaj   +1 more source

Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma [Elektronisk resurs] : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

, 2023
The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens.
Faresjö, Maria,, Lindholm, Heléne,, Szekeres, Ferenc,, Ejeskär, Katarina,, Mohlin, Sofie,   +4 more
core   +1 more source

Chemical Composition of Methanolic Extracts of Scutellaria orientalis L.: Digitoxin and Neocurdione Detection by Gas Chromatography/Mass Spectrometry

Pharmaceutical and Biomedical Research, 2022
Background: Scutellaria orientalis subsp. virens is a species of Scutellaria genus (the Lamiaceae family). The aqueous root extract of S. orientalis has been traditionally used by Iranians to treat neurological disorders, dermatitis, and bronchitis.
Zahra Gharari, Khadijeh Bagheri, Ali Sharafi   +2 more
doaj