Results 31 to 40 of about 6,490 (199)

Digoxin Inhibits Retinoblastoma through Suppressing a Non-canonical TGFβ Signaling Pathway. [PDF]

, 2016
Aims: Retinoblastoma is a childhood ocular tumor rapidly developing from the immature cells of the retina due to loss of functional retinoblastoma protein.
Akbari, Abolfazl., Ghassemi, Fariba., Heidari, Mansour., Karkhaneh, Reza., Mobini, Gholam Reza., Mohebbi, Masoumeh., Sadeghi, Abdolrahim., Shahrzad Kavakani, Mahshid., Sheikhzade, Maryam.   +8 more
core   +1 more source

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Respiratory Research, 2019
Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs.
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard   +9 more
doaj   +1 more source

Chemical Composition of Methanolic Extracts of Scutellaria orientalis L.: Digitoxin and Neocurdione Detection by Gas Chromatography/Mass Spectrometry

Pharmaceutical and Biomedical Research, 2022
Background: Scutellaria orientalis subsp. virens is a species of Scutellaria genus (the Lamiaceae family). The aqueous root extract of S. orientalis has been traditionally used by Iranians to treat neurological disorders, dermatitis, and bronchitis.
Zahra Gharari, Khadijeh Bagheri, Ali Sharafi   +2 more
doaj  

Estimulación de cardenólidos en brotes de Digitalis purpurea L. cultivados in vitro mediante elicitores

Revista Colombiana de Biotecnología, 2014
Digitalis purpurea L. es una de las principales fuentes de cardenólidos tales como digoxina y digitoxina. Estos fármacos son ampliamente usados en la disfunción cardíaca y para regular las arritmias del corazón.
Naivy Lisbet Pérez-Alonso, Franklyn Arana Labrada, Alina Capote Pérez, Anabel Pérez Pérez, Rafael Sosa, Angel Mollineda, Elio Jiménez González   +6 more
doaj   +1 more source

Ex vivo activity of cardiac glycosides in acute leukaemia. [PDF]

PLoS ONE, 2011
BACKGROUND: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this potential clinically. Reports have demonstrated promising in vitro
Helene Hallböök, Jenny Felth, Anna Eriksson, Mårten Fryknäs, Lars Bohlin, Rolf Larsson, Joachim Gullbo   +6 more
doaj   +1 more source

Consequences of toxic secondary compounds in nectar for mutualist bees and antagonist butterflies [PDF]

, 2016
Attraction of mutualists and defense against antagonists are critical challenges for most organisms and can be especially acute for plants with pollinating and non?pollinating flower visitors.
Agrawal, Anurag A., Jones, Patricia L.
core   +2 more sources

Drug Repurposing Against SARS-CoV-2: Targeting NSP16-NSP10 Interaction

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
Drug repurposing studies played an important role for fighting with the Covid-19 pandemic. Discovering a new drug molecule for a disease takes a very long time. However, repurposing a drug molecule developed for another disease can accelerate to find new
Sefer BADAY
doaj   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry [PDF]

, 2007
Background Structure elucidation of unknown small molecules by mass spectrometry is a challenge despite advances in instrumentation. The first crucial step is to obtain correct elemental compositions.
Tobias Kind, Oliver Fiehn, C Djerassi, S Omura, V Wray, BG Buchanan, DL Olson, JC Lindon, ME Elyashberg, JM Halket, JF Zhang, T Kind, B Seebass, S Heuerding, MP Balogh, L Sleno, A Makarov, AJ Dempster, H Budzikiewicz, JR De Laeter, J Lederberg, AL Rockwood, O Fiehn, SE Stein, W Windig, DR Scott, N Huang, AA Pontet, MD Soffer, DA Laws, HE Dayringer, M Badertscher, S Noury, JK Senior, T Morikawa, J Braun, C Steinbeck, AW Jensen, DL Wheeler, T Fink, JL Faulon, DS Wishart, QY Wu, O Fiehn, RG Dromey, C Steinbeck, AM Richard, P Murray-Rust, WD Ihlenfeldt, SR Heller, SR Heller, J Chen, JJ Irwin, F Csizmadia   +53 more
core   +2 more sources