Results 31 to 40 of about 3,653 (213)

Studies on the Accumulation of Digitoxin and the Cumulative Effect of Digitalis. [PDF]

open access: yes, 1974
This experiment was planned to determine whether the so-called “cumulative effect of digitoxin”occurs as a result of the true accumulation of digitoxin or is due to the accumulation of digitoxin induced changes.
泉, 尭
core   +1 more source

Chemical Composition of Methanolic Extracts of Scutellaria orientalis L.: Digitoxin and Neocurdione Detection by Gas Chromatography/Mass Spectrometry

open access: yesPharmaceutical and Biomedical Research, 2022
Background: Scutellaria orientalis subsp. virens is a species of Scutellaria genus (the Lamiaceae family). The aqueous root extract of S. orientalis has been traditionally used by Iranians to treat neurological disorders, dermatitis, and bronchitis.
Zahra Gharari   +2 more
doaj  

Ex vivo activity of cardiac glycosides in acute leukaemia. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this potential clinically. Reports have demonstrated promising in vitro
Helene Hallböök   +6 more
doaj   +1 more source

Stereochemical Survey of Digitoxin Monosaccharides

open access: yes, 2016
A stereochemically diverse array of monosaccharide analogues of the trisaccharide-based cardiac glycoside natural product digitoxin has been synthesized using a de novo asymmetric approach. The analogues were tested for cytotoxicity against the NCI panel
Todd A. Stueckle (1908121)   +5 more
core   +1 more source

Estimulación de cardenólidos en brotes de Digitalis purpurea L. cultivados in vitro mediante elicitores

open access: yesRevista Colombiana de Biotecnología, 2014
Digitalis purpurea L. es una de las principales fuentes de cardenólidos tales como digoxina y digitoxina. Estos fármacos son ampliamente usados en la disfunción cardíaca y para regular las arritmias del corazón.
Naivy Lisbet Pérez-Alonso   +6 more
doaj   +1 more source

A clinical evaluation of acetyl-digitoxin

open access: yes, 1956
The advantages of the pure glycosides are well known. A new cardiac glycoside like acetyl-digitoxin therefore merits careful evaluation. Stoll and Kreins,1 prepared acetyl-digitoxin from lanatoside A by enzymatic cleavage of one molecule of glucose.
John, Donald   +4 more
core   +1 more source

Catalytic Stereoselective Synthesis of β‑Digitoxosides: Direct Synthesis of Digitoxin and C1′-epi-Digitoxin

open access: yes, 2016
A mild and atom-economic rhenium­(V)-catalyzed stereoselective synthesis of β-d-digitoxosides from 6-deoxy-d-allals has been described. This β-selective glycosylation was achieved probably because of the formation of corresponding α-digitoxosides ...
Jianglong Zhu (1528864)   +2 more
core   +1 more source

Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma [Elektronisk resurs] : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

open access: yes, 2023
The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens.
Faresjö, Maria,   +4 more
core   +1 more source

Cytotoxic effects of digitoxin.

open access: yes, 2013
A: Cytotoxic effects of digitoxin (0.1 µM) expressed as Survival Index % (vs. untreated control cells) in the various leukaemia types (T-ALL, B precursor ALL, AML and CLL) and PBMC using the standard 72 h assay.
Lars Bohlin (358023)   +6 more
core   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican   +4 more
wiley   +1 more source

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