Results 11 to 20 of about 4,113 (206)

Digitoxin-induced apoptosis in ovarian granulosa cells disrupts follicular development and impairs reproductive performance [PDF]

Journal of Ovarian Research
Background Digitoxin, a cardiac glycoside from Digitalis spp., is clinically employed for heart failure and atrial fibrillation, and yet its reproductive toxicity is not well understood.
Yao Jiang, Meng Lv, YuYang Zhong, Yonghua Shi, Jing Wang, Xiaolong Yuan, Bin Ma   +6 more
doaj   +3 more sources

Digitoxin medication and cancer; case control and internal dose-response studies [PDF]

BMC Cancer, 2001
Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer
Spigset Olav, Klepp Olbjørn, Haux Johan, Tretli Steinar   +3 more
doaj   +3 more sources

Cardiac glycosides in patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis [PDF]

Frontiers in Cardiovascular Medicine
BackgroundThe prognostic benefits of cardiac glycosides in patients with heart failure and reduced ejection fraction (HFrEF) remain controversial. Although digitoxin exhibits more favorable pharmacokinetic characteristics than digoxin, its potential to ...
Dayang Wang, Dayang Wang, Xiaoqing Xu, Jingyao Lu, Jiayi Gao, Yingyu Li, Guozhong Pan, Wenhua Peng   +7 more
doaj   +2 more sources

Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides—A Unique Role of the Alpha3 Isoform of the Na⁺/K⁺-ATPase Pump [PDF]

Viruses
Cardiac glycosides (CGs), historically used to treat heart failure and arrhythmias, bind to the α subunit of the Na+/K+-ATPase pump and inhibit its activity. Their anticancer and antiviral activities are of interest.
Hong Mei, Hongyi Cai, Fengjie Liu, Rajkumar Venkatadri, Halli E. Miller, Angela J. Mathison, Hua-Yu Leo Wang, Simone C. Silva, George A. O’Doherty, Ravit Arav-Boger   +9 more
doaj   +2 more sources

Foliar application of esculin and digitoxin improve the yield quality of salt-stressed flax by improving the antioxidant defense system [PDF]

BMC Plant Biology
Background Secondary metabolites of several plants, including esculin and digitoxin, which are cardiac glycosides, were previously employed for their therapeutic effects.
Hemmat I. Khattab, Mervat Sh. Sadak, Mona G. Dawood, Fatma M. A. Elkady, Nesma M. Helal   +4 more
doaj   +2 more sources

Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods [PDF]

Scientific Reports
The solubility of medications in supercritical solvent is the most important factor that can be determined via appropriate computational tools. This work explores the modeling of digitoxin solubility as the case study in supercritical CO2 and solvent ...
Hadil Faris Alotaibi, Waqed H. Hassan, Ahmed Kateb Jumaah Al-Nussairi, Narinderjit Singh Sawaran Singh, Ahmed Salah Al-Shati, M. M. Rekha, Subhashree Ray, Aashna Sinha, Gunjan Garg   +8 more
doaj   +2 more sources

Click chemistry-based synthesis of fluorescent digitoxin derivatives with anticancer activity and cellular imaging potential [PDF]

RSC Advances
Cardiac glycosides are secondary plant metabolites with considerable potential as therapeutic agents in cancer treatment. However, digitoxin (Dg), one of the most studied members of this class, is reported to exhibit dose-limiting systemic toxicity and ...
Jiří Bejček, Michal Jurášek, Monika Kreisslová, Jan Škubník, Ivana Křížová, Jan Fähnrich, Soňa Gurská, Petr Džubák, Marián Hajdúch, Vojtěch Spiwok, Pavel Drašar, Tomáš Ruml, Silvie Rimpelová   +12 more
doaj   +2 more sources

Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

, 2023
The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens.
Lindholm, Heléne
core   +7 more sources

MSI: A Mahalanobis-Based Molecular Similarity Index for High-Dimensional Embeddings. [PDF]

Mol Inform
MSI pairs continuous Mol2Vec embeddings with a covariance‐aware Mahalanobis metric (dM, θM) to overcome the ranking ties and bit‐density bias of Tanimoto fingerprints. Across five reference compounds, MSI resolves more distinct neighbors than ECFP4 + Tanimoto and its geometry tracks HOMO–LUMO gaps in QM9, despite no electronic training.
Bernal-Jaquez R, Ridout-Buhl E, Montoya E, Alday-Toledo L, Aparicio F.   +4 more
europepmc   +2 more sources

Digitoxin Antagonism by Visnadin

Journal of Pharmaceutical Sciences, 1962
Visnadin, a lactone derived from bishop's weed, has been found to have marked antidotal properties in animals poisoned with digitoxin. It increases survival on acute and chronic administration of the glycoside, prevents the appearance of bradycardia, and reverses cardiac arrhythmias.
Varonos, D.D., Voukydes, P.C., Nikitopoulou, G.C.   +2 more
openaire   +4 more sources