Results 101 to 110 of about 4,113 (206)

Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A

Discover Pharmaceutical Sciences
Several cardiac glycosides, including digoxin, digitoxin, and proscillaridin A, have been originally identified as cardiomyocyte modulators and are currently being investigated for their anticancer properties.
Shreya Somani, Lekhya Menta, Feng Wang-Johanning, Gary Johanning, Seoyeon Hong, Edward Njoo   +5 more
doaj   +1 more source

Exploring bacterial key genes and therapeutic agents for breast cancer among the Ghanaian female population: Insights from In Silico analyses.

PLoS ONE
Breast cancer (BC) is yet a significant global health challenge across various populations including Ghana, though several studies on host-genome associated with BC have been investigated molecular mechanisms of BC development and progression, and ...
Md Kaderi Kibria, Md Ahad Ali, Md Nurul Haque Mollah   +2 more
doaj   +1 more source

No Drawbacks for Digitoxin [PDF]

Deutsches Ärzteblatt international, 2018
openaire   +2 more sources

Biliary excretion of digitoxin and its metabolites in cats. [PDF]

The biliary excretion products after i. v. administration of 3H-digitoxin were studied in biliary fistula induced cats and the following results were obtained : 1) Approximately 9.7% of a given dose was excreted in bile for 24 hours.
吉田, 康彦
core   +1 more source

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

, 2012
Modulation of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human diseases. We investigated the mechanism by which digitoxin, a member of the cardiotonic steroid class of drugs, regulates alternative ...
Anderson, Erik S., Stoilov, Peter, Black, Douglas L., Xiao, Xinshu, Burge, Christopher B, Lin, Chia-Ho   +5 more
core   +1 more source

Biotransformation of Digitoxin by Aspergillus Ochraceus

, 2011
Biotransformations of natural products have great potential for preparation of lead compounds. In this paper, the biotransformation of digitoxin (1) with Aspergillus ochraceus afforded two products, identified as digitoxigenin (2) and sarmentogenin (3 ...
Yan Jun Shen, Yu Wan Fu, Min Wang, Xi Chen, Hua Sun   +4 more
core   +1 more source

PRESCRIPTION OF DRUGS

Iranian Journal of Public Health, 1979
One hundred and fifteen prescriptions which were purposely written in toxic and potentially fatal dose of different medicine (mainly digitoxin) were sent to pharmacies throughout Iran.
H. Rownaghi, N. Abdolrassolnia, S. Amidi   +2 more
doaj  

Effects of digitoxin on DNA synthesis in leukaemic cell lines.

, 2013
Effects of digitoxin exposure on DNA synthesis (i.e. thymidine incorporation) in CCRF-CEM (A) and SUP-B15 (B) cells. The DNA polymerase inhibitor aphidicolin (15 µM) was used as a positive control. Effects of digitoxin exposure on protein synthesis (i.e.
Lars Bohlin (358023), Rolf Larsson (73378), Helene Hallböök (358020), Mårten Fryknäs (72946), Anna Eriksson (176834), Jenny Felth (358021), Joachim Gullbo (358025)   +6 more
core   +1 more source

Role of Na⁺/K⁺-ATPase and Sodium–Calcium Exchanger in Digitoxin-Induced Cytotoxicity in Triple Negative Breast Cancer Cells

Triple Negative Breast Cancer (TNBC) is characterized by the absence of estrogen, progesterone, and HER2 receptors, limiting targeted treatment options.
Odom, Marilyn, PhD, Sotomayor Quispe, Alyson   +1 more
core  

Repeated Doses of Activated-charcoal and Cholestyramine for Digitoxin Overdose - Pharmacokinetic Data and Urinary Elimination

, 1991
A 48-year-old man chronically treated with digitoxin and verapamil for prevention of atrial fibrillation voluntarily ingested 2.2 mg of digitoxin. Serum digitoxin concentrations and the urinary elimination of the drug were followed over a 12-day period.
Vandenplas, Olivier, Hantson, Philippe, Wallemacq, Pierre, Hassoun, A., Mahieu, P.   +4 more
core