Results 131 to 140 of about 62,419 (246)

Phenotypes and Clinical Outcome of Heart Failure With Preserved Ejection Fraction Patients in China: Findings From the Chinese Cardiovascular Association Database‐Heart Failure Center Registry

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Structured graphical abstract‐text element Key Question It remains unclear whether patients with heart failure with preserved ejection fraction (HFpEF) in different phenotypes also have various clinical outcomes. Key Finding Significant differences existed in baseline characteristics and outcomes among different phenotypes; patients with HFpEF‐3 (right
Shuai Yuan   +14 more
wiley   +1 more source

Effect of green tea catechins on the pharmacokinetics of digoxin in humans

open access: yesDrug Design, Development and Therapy, 2018
Tae-Eun Kim,1 Kwang-Hee Shin,2 Jeong-Eun Park,2 Min-Gul Kim,3 Yeo-Min Yun,4 Dong-Hee Choi,5 Kyoung Ja Kwon,5 Jongmin Lee6 1Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, Republic of Korea; 2Department of Pharmacotherapy ...
Kim TE   +7 more
doaj  

Does digoxin decrease morbidity for those in sinus rhythm with heart failure? [PDF]

open access: yes, 2005
In patients with congestive heart failure due to systolic dysfunction who are in normal sinus rhythm, digoxin therapy reduces rates of hospitalization, as well as clinical deterioration, defined as worsening New York Heart Association (NYHA ...
Fotinos, Charissa, Nashelsky, Joan
core  

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Individual dosage of digoxin in patients with heart failure [PDF]

open access: yes, 2017
Backgroud: After the publication of DIG trial, the therapeutic target of serum digoxin concentration (SDC) for the treatment of heart failure (HF) has been lowered (0.40-1.00 ng/ml).
Brunner-La Rocca, H.   +6 more
core  

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao   +5 more
wiley   +1 more source

PREPARATION OF IMMUNOGEN AND PURIFICA¬TION OF HIGH AFFINITY AND SPECIFICITY FAB FRAGMENT OF ANTI-DIGOXIN POLYCLONAL ANTIBODIES

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2000
In this study we produced and purified a high titer of specific and high affin¬ity Fab fragments of anti-digoxin antibody. Immunization of rabbits with a conju¬gate of the cardiac glycoside digoxin, coupled by a periodate oxidation method to the amino ...
M. Pour-Amir   +4 more
doaj  

Early Identification of Cardiovascular Adverse Events Associated With Rofecoxib Using Real‐World Data From the UK: A Nested Case–Control and Case‐Crossover Study

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Background Traditional pharmacovigilance systems have limitations in detecting common adverse drug reactions. We investigated whether real‐world data (RWD) could have detected rofecoxib's cardiovascular adverse effects earlier using nested case–control (NCC) and case‐crossover (CCO) designs.
Donya Moslemzadeh   +5 more
wiley   +1 more source

Development of a High‐Risk Medication List for Australian Residential Aged Care: A Modified Delphi Study

open access: yesAustralasian Journal on Ageing, Volume 45, Issue 1, March 2026.
ABSTRACT Introduction High‐risk medications are medications associated with significant patient harm or death if misused or used in error. This study aimed to develop a national consensus high‐risk medication list for use in Australian residential aged care.
Amanda J. Cross   +33 more
wiley   +1 more source

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