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Digoxin–mortality: randomized vs. observational comparison in the DIG trial
European Heart Journal, 2019 Aims The Digitalis Investigation Group (DIG) trial, the only large randomized trial of digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in heart failure hospitalizations.
, Kristina Weber, Udo Bavendiek
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Progress in Cardiovascular Diseases, 2002
After 200 years of use, digitalis still appears to have a place in our armamentarium for heart failure and atrial fibrillation despite the proven survival benefits with ACE inhibitors and beta-blockers. Digoxin therapy is inexpensive and well tolerated and may result in considerable savings.
Eric J, Eichhorn, Mihai, Gheorghiade
openaire +2 more sources
After 200 years of use, digitalis still appears to have a place in our armamentarium for heart failure and atrial fibrillation despite the proven survival benefits with ACE inhibitors and beta-blockers. Digoxin therapy is inexpensive and well tolerated and may result in considerable savings.
Eric J, Eichhorn, Mihai, Gheorghiade
openaire +2 more sources
Nephron, 2017
In a recent issue of Nephron, Abu-Amer et al.[<xref ref-type="bibr" rid="ref1">1</xref>] reported the presence of hypermagnesuria in patients following acute intravenous administration of digoxin and suggested that the Na<sup>+</sup>/K<sup>+</sup>-ATPase γ-subunit, which is the pharmacological target of digoxin, can ...
Zanoli, Luca +2 more
openaire +4 more sources
In a recent issue of Nephron, Abu-Amer et al.[<xref ref-type="bibr" rid="ref1">1</xref>] reported the presence of hypermagnesuria in patients following acute intravenous administration of digoxin and suggested that the Na<sup>+</sup>/K<sup>+</sup>-ATPase γ-subunit, which is the pharmacological target of digoxin, can ...
Zanoli, Luca +2 more
openaire +4 more sources
Anti‐Digoxin Antibody in Digoxin Intoxication
Australian and New Zealand Journal of Medicine, 1981Abstract: This study was conducted to investigate the action of anti‐digoxin antibody in digoxin intoxication. Anti‐digoxin antibody was raised in sheep and administered to six dogs following intravenous infusion of digoxin (0.04 or 0.16mg/kg body weight), either as whole serum or as partially purified gamma globulin. Plasma and urine digoxin levels,
M. F. O'Rourker +2 more
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Digoxin in hyperthyroidism [PDF]
Clinical Pharmacology & Therapeutics, 1977 A patient with chronic atrial fibrillation developed hyperthyroidism. Increasing doses of digoxin were required to maintain satisfactory ventricular rate control. The systemic availability of oral digoxin was decreased in this patient. The metabolism of digoxin was studied in hyperthyroid rats.
C. D. Klaassen +2 more
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Journal of Applied Microbiology, 2019
Different endophytic fungi were isolated and screened for their digoxin‐producing ability. Strain improvement and different culture conditions were studied for more effective production of digoxin.
El-Sayed R. El-Sayed +2 more
semanticscholar +1 more source
Different endophytic fungi were isolated and screened for their digoxin‐producing ability. Strain improvement and different culture conditions were studied for more effective production of digoxin.
El-Sayed R. El-Sayed +2 more
semanticscholar +1 more source
New England Journal of Medicine, 1971
A variable or poor response to a therapeutic agent may not have its origin in the patient; it may be due to a formulation defect in the drug product administered. The most commonly recognized formulation defect in a dosage form such as a tablet is a deficiency or excess of the active ingredient.
Trieste G. Vitti +2 more
openaire +3 more sources
A variable or poor response to a therapeutic agent may not have its origin in the patient; it may be due to a formulation defect in the drug product administered. The most commonly recognized formulation defect in a dosage form such as a tablet is a deficiency or excess of the active ingredient.
Trieste G. Vitti +2 more
openaire +3 more sources
The American Journal of Cardiology, 1985
Many investigators have studied the potential interactions between calcium-channel antagonists and digoxin. Digoxin is usually well absorbed, and its excretion is dependent on renal mechanisms, primarily glomerular filtration. Several studies have reported a decrease in digoxin clearance and an increase of approximately 50% in digoxin levels when ...
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Many investigators have studied the potential interactions between calcium-channel antagonists and digoxin. Digoxin is usually well absorbed, and its excretion is dependent on renal mechanisms, primarily glomerular filtration. Several studies have reported a decrease in digoxin clearance and an increase of approximately 50% in digoxin levels when ...
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Clinical Pharmacology and Therapeutics, 1984
Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
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Serum digoxin and metabolites were assayed in plasma and urine by HPLC in 10 dialysis-dependent patients with end-stage renal failure (group I) and in five patients with comparatively normal renal function (group II) after ingestion of 150 muCi 3H-digoxin-12 alpha.
M H, Gault +6 more
openaire +2 more sources